Results 121 to 130 of about 1,388,982 (268)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

MANAGERIAL STRESS – EFFECTS AND CONSEQUENCES

DIEM : Dubrovnik International Economic Meeting, 2017
Modern managers operate in terms of globalization which presents them with larger and more difficult challenges that sometimes are not in accordance with capabilities of an individual, causing stress. Some amounts of stress can be effective in the work performance of an individual, but problem arises when the amount of stress exceeds a certain critical
Vrdoljak Raguž, Ivona, Čučuk, Ivana
openaire   +2 more sources

Bridging Effective Stress and Soil Water Retention Equations in Deforming Unsaturated Porous Media: A Thermodynamic Approach. [PDF]

Transp Porous Media, 2017
Huyghe JM, Nikooee E, Hassanizadeh SM.
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Effect of Temperature and Pressure on Effective Stress Coefficient and Permeability Prediction Model in Coal Reservoirs. [PDF]

ACS Omega
Guo C, Yang X, Shi K, Yang J, Gao J, Li R, Zhang Y, Xu J, Guo C, Shao J, Hao L.   +10 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experimental study on effective stress coefficient of sandstone based on Mohr-Coulomb criterion under hydraulic-mechanical coupling. [PDF]

Sci Rep
Chen W, Liu B, Wu Q, Liu J, Ren Z, Wang Q, Liu Z, Peng W, Zhou Y, Wang Y, Peng Z.   +10 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

The seepage model for CO₂ in Shale considering dynamic slippage, effective stress and gas adsorption. [PDF]

Sci Rep
Zhai W, Wu D, Liu X, Xiao X, Ding X, Miao F, Chen X.   +6 more
europepmc   +1 more source