Results 61 to 70 of about 8,019,498 (283)

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Thermal Properties of New Insulating Juncus Maritimus Fibrous Mortar Composites/Experimental Results and Analytical Laws

open access: yesApplied Sciences, 2019
This study aims to study the thermal properties and the microstructure of composite materials based on mortar combined with Juncus maritimus fibers. Effective thermophysical properties of the composite materials containing Juncus maritimus fibers are ...
Zahia Saghrouni   +4 more
doaj   +1 more source

An effective thermal conductivity model for fractal porous media with rough surfaces

open access: yesAdvances in Geo-Energy Research, 2019
Quantitative evaluation of the effective thermal conductivity of porous media has received wide attention in science and engineering since it is a key thermophysical parameter in characterizing heat transfer properties.
X. Qin, Yingfang Zhou, A. Sasmito
semanticscholar   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Experimental determination of efficient thermal conductivity of depth hoar

open access: yesЛëд и снег, 2015
As a result of laboratory tests, values of the effective thermal conductivity of recrystallized snow were obtained. There are big differences between the coefficient of effective thermal conductivity of depth hoar and granular snow density in the range ...
R. A. Chernov
doaj   +1 more source

The emergent behavior of three-dimensional and three-phase thermal network model for the heterogeneous materials

open access: yesAdvances in Mechanical Engineering, 2023
The study of the heat transfer properties of heterogeneous materials has been a world-wide research focus, for example in sectors related to thermal management in aerospace, architecture, and geology.
Jianhui Tian   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Applying GMDH neural network to estimate the thermal resistance and thermal conductivity of pulsating heat pipes

open access: yesEngineering Applications of Computational Fluid Mechanics, 2019
Thermal performance of pulsating heat pipes (PHPs) is dependent to several factors. Inner and outer diameter of tube, filling ratio, thermal conductivity, heat input, inclination angle, and length of each section are the most influential factors in the ...
Mohammad Hossein Ahmadi   +3 more
doaj   +1 more source

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