Results 101 to 110 of about 28,489 (306)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Effectivity functions and associated game correspondences [PDF]
Game Theory;game ...
Borm, P.E.M. +3 more
core +1 more source
Effectivity and Density in Domains A Survey [PDF]
, 1999 This article surveys the main results on effectivity and totality in domain theory and its applications. A more abstract and informative proof of Normann's generalized density theorem for total functionals of finite type over the reals is ...
Ulrich Berger, Berger, Ulrich
core +1 more source
The Structural Effectivity of Bent Piles in Ammatoan Vernacular Houses
Buildings, 2019 Ammatoa Kajang vernacular houses are buildings that have existed for a hundred years as residential house buildings. These traditional houses are unique in their use of bent piles.
Wasilah Wasilah
doaj +1 more source
EFFECTS OF LEADERSHIP ROLES ON TEAM EFFECTIVENESS
Ege Akademik Bakis (Ege Academic Review), 2009 In this study we aim to explain the patterns of leadership roles for team effectiveness in non profit organizations compared to economic organizations. For this purpose, we studied three successful organization types, i.e the amateur sports clubs (football, basketball), theater companies and, regional folk groups.
DUYGULU, Ethem, ÇIRAKLAR, Nurcan
openaire +5 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Животновъдни науки, 2015 The purpose of this study was to analyze the economical effectiveness of the implementation of scheme hormonal induction of oestrus and ovulation stimulation in sheep of Trakian merino breed.
ЙОВКА Попова +6 more
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source