Results 111 to 120 of about 8,184,686 (331)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Note on OTM-Realizability and Constructive Set Theories

, 2019
We define an ordinalized version of Kleene's realizability interpretation of intuitionistic logic by replacing Turing machines with Koepke's ordinal Turing machines (OTMs), thus obtaining a notion of realizability applying to arbitrary statements in the ...
Carl, Merlin
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Synergistic Effect of Carbon Nanotubes and Decabromodiphenyl Oxide/Sb\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e in Improving the Flame Retardancy of Polystyrene [PDF]

, 2010
Brominated flame retardant polystyrene composites were prepared by melt blending polystyrene, decabromodiphenyl oxide, antimony oxide, multi-wall carbon nanotubes and montmorillonite clay. Synergy between carbon nanotubes and clay and the brominated fire
Lu, Hongdian, Wilkie, Charles A.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Simulation of Laser Ablation in Aluminum: The Effectivity of Double Pulses

, 2014
Lasers are becoming a more and more important tool in cutting and shaping materials. Improving precision and effectivity is an ongoing demand in science and industry. One possibility are double pulses.
Krauß, Armin, Lotze, Jan, Roth, Johannes, Trebin, Hans-Rainer   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

INDONESIAN ROCK-PHOSPHATE EFFECTIVITY FOR MAIZE CROP ON ULTISOLS SOILS

AGRIVITA Journal of Agricultural Science, 2012
Rock phosphate is a slow release phosphate source which can be directly used on acid soils. There are some rock phospahate deposits in Indonesia. Total phosphate and calcium content in rock phosphate vary between 8.79 – 31.88% P2O5, and 0.60 – 57.50% Ca.
A. Kasno, M.T. Sutriadi
doaj  

Understanding the students’ learning style to enhance the effectivity of learning method: a study on accounting students

Journal of Accounting and Investment
Research aims: The study aims to test the students’ learning style preferences and investigate the influence of the lecturer's teaching methods in the accounting study program.
Nuzul Ibnu Hajar, Jamaluddin Dahlan, Khaerunnisa Ibnu Hajar   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source