Results 141 to 150 of about 657,049 (345)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ECT-induced primary open-angle glaucoma in a patient with unstable thyroid function: a case report

open access: yesFrontiers in Psychiatry
BackgroundSchizophrenia is a prevalent and severe psychiatric disorder for which electroconvulsive therapy (ECT) is frequently utilized as a treatment modality.
Cuiyuan Fu   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Proposal for Effective Management of Geoparks as a Tool for Sustainable Tourism in the Conditions of the Slovak Republic

open access: yesLand
Geoparks, as sustainable tourism products, embody a range of values and functions aimed at mitigating the negative impacts of tourism on the landscape. The current increasing trend in establishing and supporting geoparks has extended to the territory of ...
Mário Molokáč   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Икономическа ефективност и капиталоемкост при плододаващите трайни насаждения в планинските райони на страната

open access: yesИкономика и управление на селското стопанство, 2012
Статията отразява проблемите при отглеждането на ягода, малина, къпина и слива в планинските райони на страната и перспективите за тяхното развитие.
ВАЛЕНТИНА ВАЛЕРИЕВА-НЕЧОВА
doaj  

Geophysical Survey as Part of Rescue Archaeological Excavation on Large Construction Projects—Case Study: Road I/16 Slaný–Velvary (Czech Republic)

open access: yesRemote Sensing
Regions densely populated with archaeological monuments pose significant challenges for construction investors and archaeologists during the planning stages of major construction projects.
Tomáš Tencer   +2 more
doaj   +1 more source

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