Results 151 to 160 of about 28,489 (306)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Stability Index for Local Effectivity Functions [PDF]
, 2009 URL des Documents de travail : http://ces.univ-paris1.fr/cesdp/CESFramDP2009.htm Voir aussi l'article paru dans Mathematical Social Sciences : http://halshs.archives-ouvertes.fr/halshs-00389003Documents de travail du Centre d'Economie de la Sorbonne ...
Abdou, Joseph, M.
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
MONOTONICITY IMPLIES STRATEGY-PROOFNESS FOR CORRESPONDENCES [PDF]
We show that Maskin monotone social choice correspondences on sufficiently rich domains satisfy a generalized strategy-proofness property, thus generalizing Muller and Satterthwaite''s (1977) theorem to correspondences.
Klaus Nehring, Massimiliano Marcellino
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
EFFECTIVITY OF HEAT EXCHANGER USING COOLANT FLUID [PDF]
In industry, heat exchanger usually used in the manufacturing process. This research will use shell and tube heat exchanger (STHC) with coolant fluid and water. Experimental data for analysis are temperature of the fluid and flowrate.
Tanujaya, Harto
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Humanitarian Corridors: Can we do better? : A comparative study on the historical effectivity of humanitarian corridors in the delivery of aid and the factors that influence this effectivity. [PDF]
The aim of the thesis was to discover the historical effectivity of humanitarian corridors through a comparative study of four different cases and to identify factors that influence this effectivity. The focus of this research lies on the delivery of aid,
Bijl, Helena Wilhelmina Adriana
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Effectivity of Insolvency Proceedings [PDF]
, 2018 Conditions for exit of business subjects from a business environment is one of important circumstances that participate on the over-all quality of the particular business environment.
Louda, Lee
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