Results 91 to 100 of about 716,867 (257)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Unraveling the Entry Mechanism of Oomycete and Fungal Effector Proteins into host cells [PDF]

, 2015
Oomycetes and fungi facilitate pathogenesis via secretion of effector proteins that have apoplastic and intracellular localizations. These effector proteins have a diverse array of functions that aid in pathogenesis, including modification of defense ...
Lawrence, D., GU, B., Rumore, A. C., Shan, C. B., Tyler, B. M., Capelluto, Daniel G. S., Kale, Shiv D.   +6 more
core  

Nuclear processes associated with plant immunity and pathogen susceptibility [PDF]

, 2015
Plants are sessile organisms that have evolved exquisite and sophisticated mechanisms to adapt to their biotic and abiotic environment. Plants deploy receptors and vast signalling networks to detect, transmit and respond to a given biotic threat by ...
Kulagina, Natalja, Huitema, Edgar; id_orcid, Motion, Graham B., Marques Monteiro Amaro, Tiago M.   +3 more
core   +1 more source

Secretion of Salmonella Pathogenicity Island 1-Encoded Type III Secretion System Effectors by Outer Membrane Vesicles in Salmonella enterica Serovar Typhimurium

Frontiers in Microbiology, 2018
Outer membrane vesicles (OMVs) are spherical membranous structures released by Gram-negative bacteria. Several bacterial pathogens utilize OMVs as vehicles for the delivery of virulence factors into host cells.
Seul I Kim, Seongok Kim, Eunsuk Kim, Seo Yeon Hwang, Hyunjin Yoon, Hyunjin Yoon   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A translocated effector required for bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors [PDF]

, 2013
Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions. These effectors may interfere with each other to efficiently control the infection process.
Okujava, Rusudan, Dehio, Christoph, Polus, F, Guye, Patrick, Muriel Vayssier-Taussat, Rusudan Okujava, Florine Polus (580547), Cornelia Halin (574950), Halin, Cornelia, Patrick Guye, Cornelia Halin, Polus, Florine, Christoph Dehio, Okujava, R, Guye, P, Florine Polus, Halin, C, Vayssier-Taussat, M, Vayssier-Taussat, Muriel, Vayssier Taussat, Muriel, Muriel Vayssier-Taussat (247536), Claudia Mistl (580546), Yun-Yueh Lu (182156), Christoph Dehio (200951), Yun-Yueh Lu, Rolink, Antonius G., Antonius G. Rolink (268388), Antonius G Rolink, Lu, Y, Mistl, C, Dehio, C, Lu, Yun-Yueh, Mistl, Claudia, Rolink, AG, Rusudan Okujava (580545), Patrick Guye (200949), Claudia Mistl   +36 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Unveiling the Slippery Secrets of Saliva: Effector Proteins of Phloem-Feeding Insects

Molecular Plant-Microbe Interactions
Phloem-feeding insects include many important agricultural pests that cause crop damage globally, either through feeding-related damage or upon transmission of viruses and microbes that cause plant diseases. With genetic crop resistances being limited to
Jade R. Bleau, Namami Gaur, Yao Fu, Jorunn I. B. Bos   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Large-Scale Identification and Characterization of Heterodera avenae Putative Effectors Suppressing or Inducing Cell Death in Nicotiana benthamiana

Frontiers in Plant Science, 2018
Heterodera avenae is one of the most important plant pathogens and causes vast losses in cereal crops. As a sedentary endoparasitic nematode, H. avenae secretes effectors that modify plant defenses and promote its biotrophic infection of its hosts ...
Changlong Chen, Changlong Chen, Yongpan Chen, Heng Jian, Dan Yang, Yiran Dai, Lingling Pan, Lingling Pan, Fengwei Shi, Fengwei Shi, Shanshan Yang, Qian Liu   +11 more
doaj   +1 more source