Results 81 to 90 of about 716,867 (257)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

The lectin receptor kinase LecRK-I.9 is a novel Phytophthora resistance component and a potential host target for a RXLR effector [PDF]

, 2011
In plants, an active defense against biotrophic pathogens is dependent on a functional continuum between the cell wall (CW) and the plasma membrane (PM). It is thus anticipated that proteins maintaining this continuum also function in defense. The legume-
Sofieke Klamer, Govers Francine, Weide, R., Mara de Sain, Rob Weide, Anne Gouget, Canut Herve, Govers, F., de Sain Mara, Weide Rob, Gouget, A., Herve Canut, Francine Govers, de Sain, M., Bouwmeester Klaas, Canut, H., Klaas Bouwmeester, Gouget Anne, Sain, M., de, Klamer, S., Bouwmeester, K., Klamer Sofieke   +21 more
core   +2 more sources

A transient homotypic interaction model for the influenza A virus NS1 protein effector domain [PDF]

, 2011
Influenza A virus NS1 protein is a multifunctional virulence factor consisting of an RNA binding domain (RBD), a short linker, an effector domain (ED), and a C-terminal 'tail'. Although poorly understood, NS1 multimerization may autoregulate its actions.
Margaret A Taylor, Richard E. Randall, García-Sastre, A., Hale Benjamin G., Kerry, P.S., Lewis Andrew, Taylor Margaret A., Kerry, Philip S., Andrew Lewis, Kerry Philip S., Hass, C., Benjamin G. Hale, Hale, Benjamin G., Rupert J. Russell, Juan Ayllon, Richard E Randall, Randall Richard E., Hale, B.G., Margaret A. Taylor, Ayllon, Juan, Philip S Kerry, Randall, R.E., Adolfo García-Sastre, Ayllón Barasoain, Juan, Lewis, Andrew, Hass Claudia, Ayllon, J., Rupert J Russell, García Sastre, Adolfo, Taylor, M.A., Lewis, A., García-Sastre Adolfo, Taylor, Margaret A., Hass, Claudia, Ayllon Juan, Russell, R.J., Randall, Richard E., Claudia Hass, Russell, Rupert J., Benjamin G Hale, Russell Rupert J., Philip S. Kerry, Garcia-Sastre, Adolfo   +42 more
core   +1 more source

The tomato Prf complex is a molecular trap for bacterial effectors based on Pto transphosphorylation [PDF]

, 2013
The bacteria Pseudomonas syringae is a pathogen of many crop species and one of the model pathogens for studying plant and bacterial arms race coevolution.
John P Rathjen, Rathjen, John P, Alexi L. Balmuth, Vardis Ntoukakis, Balmuth, Alexi L, Balmuth, Alexi L., Ra M. E. Jones, Tatiana S Mucyn, Gutierrez, Jose R., Jose R. Gutierrez, Mucyn, Tatiana S, Alexi L. Balmuth, Vardis Ntoukakis (223009), Ntoukakis Vardis, Jose R. Gutierrez (278825), Ntoukakis, Vardis, Alexi L. Balmuth (215165), John P. Rathjen (232061), Jose R Gutierrez, Gutierrez, Jose R, Balmuth Alexi L., Vardis Ntoukakis, Jones, Alexandra M., Tatiana S. Mucyn (278824), Jones, Alexandra M. E, Tatiana S. Mucyn¤a, Rathjen John P., Rathjen, John P., Alexi L Balmuth, Jones Alexandra M. E., Mucyn, Tatiana S., John P. Rathjen*¤b, Alexandra M. E. Jones, Gutierrez Jose R., John P. Rathjen, Alexandra M. E. Jones (50010), Tatiana S. Mucyn, Alexandra M E Jones, Mucyn Tatiana S.   +38 more
core   +2 more sources

Identification and characterisation of a hyper-variable apoplastic effector gene family of the potato cyst nematodes [PDF]

, 2014
Date of Acceptance: 11/08/2014Sedentary endoparasitic nematodes are obligate biotrophs that modify host root tissues, using a suite of effector proteins to create and maintain a feeding site that is their sole source of nutrition. Using assumptions about
Jones, John T., John T Jones, Peter E. Urwin (183000), Eves-van den Akker, Sebastian, John T. Jones, Lilley, Catherine J., Jones John T., Urwin, Peter E., Catherine J Lilley, Eves-van den Akker Sebastian, Catherine J. Lilley (182995), Peter E. Urwin, Sebastian Eves-van den Akker (515790), Lilley Catherine J., Catherine J. Lilley, Sebastian Eves-van den Akker, Urwin Peter E., Peter E Urwin, John T. Jones (207247)   +18 more
core   +2 more sources

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans [PDF]

, 2011
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P, Chung-Ching Chu, Francesca Capon, Di Meglio, Paola, Napolitano, Luca, Napolitano, L, Ketty Peris, Di Cesare, Antonella, Villanova, Federica, Villanova, F, Richard C. Trembath, Isabella Tosi, Paola Di Meglio, Richard C Trembath, Laggner, Ute, Chu, Chung-Ching, Chu, CC, Capon, Francesca, Federica Villanova, Frank O Nestle, Nestle, FO, Peris, K, Nestle, Frank O., Antonella Di Cesare, Peris, Ketty, Trembath, RC, Laggner, U, Tosi, Isabella, Luca Napolitano, Capon, F, Frank O. Nestle, Ute Laggner, Trembath, Richard C., Di Cesare, A, Tosi, I   +34 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effector identification in the lettuce downy mildew Bremia lactucae by massively parallel transcriptome sequencing [PDF]

, 2012
Lettuce downy mildew (Bremia lactucae) is a rapidly adapting oomycete pathogen affecting commercial lettuce cultivation. Oomycetes are known to use a diverse arsenal of secreted proteins (effectors) to manipulate their hosts.
Cuppen, E., Stassen, J.H.M., Sub Plant-Microbe Interactions, van den Ackerveken, A.F.J.M., Sub Theoretical Biology & Bioinformatics, Theoretical Biology and Bioinformatics, Nijman, I.J., Snel, B., Vergeer, P.W.J., Plant Microbe Interactions, Seidl, M.F.   +10 more
core   +2 more sources

Recent advances in the Zymoseptoria tritici – wheat interaction; Insights from pathogenomics

Frontiers in Plant Science, 2015
We examine the contribution of next generation sequencing (NGS) to our understanding of the interaction between the fungal pathogen Zymoseptoria tritici and its wheat host. Recent interspecific whole genome comparisons between Z.
Megan eMcDonald, Bruce eMcDonald, Peter eSolomon   +2 more
doaj   +1 more source