Results 141 to 150 of about 13,977,700 (260)

Role of PD-1 during effector CD8 T cell differentiation

Proceedings of the National Academy of Sciences of the United States of America, 2018
Eunseon Ahn, K. Araki, M. Hashimoto, Weiyan Li, J. Riley, Jeanne Cheung, A. Sharpe, G. Freeman, B. Irving, R. Ahmed   +9 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Altered Endometrial Memory T-Cell Profiles During the Window of Implantation in Women with Previous Miscarriage. [PDF]

Biomedicines
Parvanov D, Ganeva R, Ruseva M, Handzhiyska M, Safir J, Jelezarsky L, Metodiev D, Stamenov G, Hadjidekova S.   +8 more
europepmc   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Single-cell multiomics reveals macrophage-derived IL-23 and CXCL9/10 drive pathogenic IFNG⁺IL17⁺ T cells in immunotherapy-related colitis. [PDF]

J Immunother Cancer
Tang Z, Shi J, Xu S, Liu S, Yin W, Xiang Y, Li J, He Z, Yao X, Li Z, Xiao R, Deng H.   +11 more
europepmc   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Phytophthora infestans RxLR Effector PiAvr3b Targets NADP-Malic Enzyme to Promote Infection. [PDF]

Mol Plant Pathol
Gao W, Gu B, Liu C, Zhang X, Liu Q, Zhang Y, Liu X.   +6 more
europepmc   +1 more source

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Science, 2001
D. Masopust, V. Vezys, A. Marzo, L. Lefrançois   +3 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Pathogenicity and virulence of <i>Phytophthora infestans</i>: The ever-evolving threat to food security and its sustainable management strategies. [PDF]

Virulence
Wang WJ, Li J, Zhao G, Wang YP, Fan S, Dong YQ, Yang LN, Zhan J.   +7 more
europepmc   +1 more source