Results 151 to 160 of about 929,086 (308)

Correction: Nattokinase-driven remodeling of tumor microenvironment enhances the efficacy of MSLN-targeted CAR-T cell therapy in solid tumors. [PDF]

Cancer Immunol Immunother
Zhao L, Zhang Y, Yang X, Chen T, Liu J, Guo Z.   +5 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Conserved 'Late' Effector Genes From Leptosphaeria maculans Inducing Gene-For-Gene Quantitative Resistance in Brassica napus Semi-Winter Genotypes. [PDF]

Mol Plant Pathol
Rabeau C, Wagner A, Lapalu N, Jiquel A, Faure S, Fudal I.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Design for a Three-Fingered Hand [PDF]

A general purpose end-effector for use on the space manipulator proposed for the shuttle program was developed. The end-effector has the capabilities of a human hand and peel-off value as a human prosthetic device.
Crossley, F. R. E., Umholtz, F. G.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Reconfigurable analysis and workspace optimization of modular cable-suspended parallel robot. [PDF]

Sci Rep
Zhao T, Dai W, Zheng F, Lou X, Qian S, Zi B.   +5 more
europepmc   +1 more source

Cell mediated cytotoxicity against Sendai virus infected cells [PDF]

, 1976
Bevan, Bhatnagar, Brunner, Gardner, Gardner, Gordon, Julius, Kedar, Kieling, Koszinowski, Koszinowski, Koszinowski, Lagrange, Lesley, Mcfarland, Pfizenmaier, Rehn, Reif, Schmitt-Verhulst, Shearer, Wagner, Zinkernagel   +21 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Characterization of the Effector Candidate Repertoire in the Arbuscular Mycorrhizal Fungus <i>Rhizophagus irregularis</i>. [PDF]

J Fungi (Basel)
Huang Y, Bi L, Zhu Y, Chen L, Yao R.
europepmc   +1 more source