Regulatory T cells in breast cancer drivers of immune suppression and targets for immunotherapy. [PDF]
Pan T +5 more
europepmc +1 more source
Effector T Cells in Multiple Sclerosis.
B. Kaskow, C. Baecher-Allan
semanticscholar +1 more source
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity. [PDF]
Liseth O +14 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
What makes a mycoparasite? Candidate effectors from fungi that parasitize other fungi exhibit structural homology to those of fungal plant pathogens. [PDF]
Sotiropoulos AG +3 more
europepmc +1 more source
The effector repertoire of Legionella [PDF]
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Vaccines: Effector and memory T-cell differentiation: implications for vaccine development
S. Kaech, E. Wherry, R. Ahmed
semanticscholar +1 more source

