Results 231 to 240 of about 18,481,212 (402)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Chromatin landscape alteration uncovers multiple transcriptional circuits during memory CD8+ T-cell differentiation. [PDF]

Protein Cell
Liu Q, Dong W, Liu R, Xu L, Ran L, Xie Z, Lei S, Su X, Yue Z, Xiong D, Wang L, Wen S, Zhang Y, Hu J, Qin C, Chen Y, Zhu B, Chen X, Wu X, Xu L, Huang Q, Cao Y, Ye L, Tang Z.   +23 more
europepmc   +1 more source

An experimental study of the effect of four speech variables on listener comprehension∗

, 1952
K. C. Beighley
openalex   +2 more sources

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity. [PDF]

Front Med (Lausanne)
Gaskarth DA, Fan S, Highton AJ, Kemp RA.
europepmc   +1 more source

The effector repertoire of Legionella [PDF]

Nature Reviews Microbiology, 2019
openaire   +3 more sources

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells. [PDF]

Proc Natl Acad Sci U S A
Kao KS, Pihlstrom NL, Niejadlik EG, Cantaert T, Ahmed R, Ravetch JV, Bournazos S.   +6 more
europepmc   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Different CMV-specific effector T cell subtypes are associated with age, CMV serostatus, and increased systolic blood pressure. [PDF]

Immun Ageing
Roesner LM, Bošnjak B, Traidl S, Huehn J, Förster R, Werfel T.   +5 more
europepmc   +1 more source