Results 261 to 270 of about 5,384,327 (358)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The Signal Peptidase MoSpc2 Orchestrates Fungal Development, Protein Secretion and Pathogenicity in Magnaporthe oryzae. [PDF]

Rice (N Y)
Tang W, Wang M, Bao Y, Chen W, Jiang Y, Chen M, Chen X, Yun Y, Wang Z, Chen X.   +9 more
europepmc   +1 more source

Elementary immunology [PDF]

, 2017
Gogolák, Péter, Koncz, Gábor
core  

Discipline or Disruption? Stakeholder Relationships and the Effect of Takeover Threat

, 2015
Ling Cen, Sudipto Dasgupta, Rik Sen
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Validation and subcellular localization of previously predicted type III secreted effector proteins in <i>Chlamydia trachomatis</i>. [PDF]

Microbiol Spectr
McCaslin PN, Andersen SE, Smith P, Weber MM, Faris R.   +4 more
europepmc   +1 more source

Acetate promotes T cell effector function during glucose restriction [PDF]

, 2019
Egawa, Takeshi, et al,, Maggi, Leonard B, Jr.   +2 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Identification and functional analysis of putative effector proteins from <i>Diaphorina citri</i> and '<i>Candidatus</i> Liberibacter asiaticus'. [PDF]

Front Plant Sci
Dangol S, Leite MFA, Alves MN, Galland M, van Kleeff PJM, Kramer G, Darolt JC, Raiol-Junior LL, Garcia RB, Peña L, Wulff NA, de Miranda MP, Lopes SA, Bouwmeester H, Schuurink RC.   +14 more
europepmc   +1 more source