Results 171 to 180 of about 2,070,236 (251)

Speaking the host language: how <i>Salmonella</i> effector proteins manipulate the host. [PDF]

Microbiology (Reading), 2023
Pillay TD, Hettiarachchi SU, Gan J, Diaz-Del-Olmo I, Yu XJ, Muench JH, Thurston TLM, Pearson JS.   +7 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Identification and functional analysis of putative effector proteins from <i>Diaphorina citri</i> and '<i>Candidatus</i> Liberibacter asiaticus'. [PDF]

Front Plant Sci
Dangol S, Leite MFA, Alves MN, Galland M, van Kleeff PJM, Kramer G, Darolt JC, Raiol-Junior LL, Garcia RB, Peña L, Wulff NA, de Miranda MP, Lopes SA, Bouwmeester H, Schuurink RC.   +14 more
europepmc   +1 more source

Identification and Preliminary Characterization of Novel Type III Secreted Effector Proteins in Chlamydia trachomatis. [PDF]

Infect Immun, 2023
McCaslin PN, Andersen SE, Icardi CM, Faris R, Steiert B, Smith P, Haider J, Weber MM.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Correction: Brucella modulates secretory trafficking via multiple Type IV secretion effector proteins. [PDF]

PLoS Pathog
Myeni S, Child R, Ng TW, Kupko Iii JJ, Wehrly TD, Porcella SF, Knodler LA, Celli J.   +7 more
europepmc   +1 more source

Ab Initio Modelling of the Structure of ToxA-like and MAX Fungal Effector Proteins. [PDF]

Int J Mol Sci, 2023
Rozano L, Mukuka YM, Hane JK, Mancera RL.   +3 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The SPI-20 and SPI-21 T6SS gene clusters from <i>Salmonella enterica</i> subspecies <i>arizonae</i> encode effector proteins that display antibacterial activity. [PDF]

Front Microbiol
Parra-Calisto A, Blondel CJ, Vargas-Del Río C, Fernández-Castillo E, Reyes-Méndez F, Soriano-Mora V, Avilés A, Toledo V, Salazar-Salas F, Espinoza-Jara P, Amaya FA, Santiviago CA, Asenjo JA, Pezoa D.   +13 more
europepmc   +1 more source