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Small-Molecule Inhibitors of the Type III Secretion System [PDF]
Molecules, 2015 Drug-resistant pathogens have presented increasing challenges to the discovery and development of new antibacterial agents. The type III secretion system (T3SS), existing in bacterial chromosomes or plasmids, is one of the most complicated protein ...
Lingling Gu +4 more
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Natural Product Type III Secretion System Inhibitors [PDF]
Antibiotics, 2019 Many known inhibitors of the bacterial type III secretion system (T3SS), a virulence factor used by pathogenic bacteria to infect host cells, are natural products.
Heather A. Pendergrass, Aaron E. May
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<i>Salmonella</i> Type III Secretion System Effectors. [PDF]
Int J Mol SciSalmonella is estimated to infect between 200 million and over 1 billion people per year. The exact number is not known, as many cases go unreported. Integral to the pathogenesis of Salmonella, as well as numerous other Gram-negative pathogens, is its type III effectors.
Worley MJ.
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Animal Models of Type III Secretion System-Mediated Pathogenesis
Pathogens, 2019 The type III secretion system (T3SS) is a conserved virulence factor used by many Gram-negative pathogenic bacteria and has become an important target for anti-virulence drugs.
Julia A. Hotinger, Aaron E. May
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Plasmid replication initiator protein TrfA represses the host type III secretion system in Pseudomonas aeruginosa [PDF]
mBioPseudomonas aeruginosa is an environmental bacterium and opportunistic human pathogen capable of causing a wide range of infections in humans. The type III secretion system (T3SS) plays a key role in the pathogenesis of acute P.
Yu Zhang +11 more
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Regulation of the Type III Secretion System in Phytopathogenic Bacteria [PDF]
Molecular Plant-Microbe Interactions, 2006 The type III secretion system (TTSS) is a specialized protein secretion machinery used by numerous gram-negative bacterial pathogens of animals and plants to deliver effector proteins directly into the host cells.
Xiaoyan Tang, Yanmei Xiao, Jian-Min Zhou
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Biomolecules, 2021 The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable
Julia A. Hotinger +2 more
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Antibodies Inhibiting the Type III Secretion System of Gram-Negative Pathogenic Bacteria
Antibodies, 2020 Pathogenic bacteria are a global health threat, with over 2 million infections caused by Gram-negative bacteria every year in the United States. This problem is exacerbated by the increase in resistance to common antibiotics that are routinely used to ...
Julia A. Hotinger, Aaron E. May
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Type III Secretion System in Intestinal Pathogens and Metabolic Diseases [PDF]
Journal of Diabetes ResearchModern lifestyle changes, especially the consumption of a diet high in salt, sugar, and fat, have contributed to the increasing incidence and prevalence of chronic metabolic diseases such as diabetes, obesity, and gout.
Le Zhou +6 more
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The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence
Biomolecules, 2023 Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C.
Amber D. Gabbert +7 more
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