Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components. [PDF]
Biomolecules, 2021 The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable of causing systemic infection, the T3SS has emerged as an attractive anti-virulence target for ...
Hotinger JA, Pendergrass HA, May AE.
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mBio, 2022 The intracellular EscE protein tightly controls the secretion of the type III secretion system (T3SS) middle and late substrates in Edwardsiella piscicida. However, the regulation of secretion by EscE is incompletely understood.
Zhi Xiong Zeng +11 more
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Protein Export via the Type III Secretion System of the Bacterial Flagellum [PDF]
Biomolecules, 2021 The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner.
Manuel Halte, Marc Erhardt
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Coordination of quorum sensing with T3SS and T6SS: Bacterial strategies for combating fungal pathogens [PDF]
VirulenceBacterial-fungal interactions are essential for ecosystem balance, where secretion systems like the Type III Secretion System (T3SS) and Type VI Secretion System (T6SS) play crucial roles.
Yuanyuan Ma +5 more
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Piericidin A1 Blocks
mSphere, 2017 The type III secretion system (T3SS) is a bacterial virulence factor expressed by dozens of Gram-negative pathogens but largely absent from commensals.
Jessica M. Morgan +10 more
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PA5201 represses type III secretion system by binding to the PexsC promoter in Pseudomonas aeruginosa [PDF]
Microbiology SpectrumThe type III secretion system (T3SS) is a major virulence determinant in Pseudomonas aeruginosa, which is activated by the master regulator ExsA. exsA is transcribed from two distinct promoters: its operon promoter PexsC and its own promoter PexsA. Here,
Lepeng Wang +10 more
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Bcr4 Is a Chaperone for the Inner Rod Protein in the Bordetella Type III Secretion System
Microbiology Spectrum, 2022 Bordetella bronchiseptica injects virulence proteins called effectors into host cells via a type III secretion system (T3SS) conserved among many Gram-negative bacteria.
Masataka Goto +4 more
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Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates. [PDF]
PLoS ONE, 2014 Pseudomonas aeruginosa is a frequent cause of acute infections. The primary virulence factor that has been linked to clinical disease is the type III secretion system, a molecular syringe that delivers effector proteins directly into host cells.
Jonida Toska +6 more
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Engineering Agrobacterium tumefaciens with a Type III Secretion System to Express Type III Effectors
Bio-Protocol, 2023 Plants elicit defense responses when exposed to pathogens, which partly contribute to the resistance of plants to Agrobacterium tumefaciens–mediated transformation.
Vidhyavathi Raman, Kirankumar Mysore
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Nature Communications, 2021 Many bacterial pathogens use a type III secretion system (T3SS) to inject effector proteins into host cells. Here, Wimmi et al. show that the external pH regulates the assembly of T3SS cytosolic components in intestinal pathogens, thus preventing T3SS ...
Stephan Wimmi +10 more
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