Results 31 to 40 of about 27,042,650 (190)

Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. [PDF]

, 2010
BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent.
Stabler, Richard A., Sunee Korbsrisate, Stevens, Mark P, Pornpan Pumirat, Ekapot Singsuksawat, Wren, Brendan W, Korbsrisate, Sunee, Singsuksawat, Ekapot, Mark P Stevens, Muangsombut, Veerachat, Veerachat Muangsombut, Cuccui, Jon, Richard A Stabler, Joanne M Stevens, Pumirat, Pornpan, Wren, Brendan W., Stabler, Richard A, Stevens, Joanne M, Stevens, Joanne M.; id_orcid, Stevens, Mark P., Jon Cuccui, Brendan W Wren, Singsuksawat Ekapot, Stevens Mark P, Cuccui Jon, Stabler Richard A, Stevens Joanne M, Korbsrisate Sunee, Wren Brendan W, Muangsombut Veerachat, Pumirat Pornpan   +30 more
core   +1 more source

Orf1B controls secretion of T3SS proteins and contributes to Edwardsiella piscicida adhesion to epithelial cells

Veterinary Research, 2022
Edwardsiella piscicida is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish. The type III secretion system (T3SS) is one of its two most important virulence islands. T3SS protein EseJ inhibits E.
Long Kun Wang, Shan Shan Sun, Shu Ya Zhang, Pin Nie, Hai Xia Xie   +4 more
doaj   +1 more source

Life After Secretion—Yersinia enterocolitica Rapidly Toggles Effector Secretion and Can Resume Cell Division in Response to Changing External Conditions

Frontiers in Microbiology, 2019
Many pathogenic bacteria use the type III secretion system (T3SS) injectisome to manipulate host cells by injecting virulence-promoting effector proteins into the host cytosol.
Bailey Milne-Davies, Carlos Helbig, Stephan Wimmi, Dorothy W. C. Cheng, Nicole Paczia, Andreas Diepold   +5 more
doaj   +1 more source

The Type III Secretion System (T3SS) ofChlamydophila psittaciIs Involved in the Host Inflammatory Response by Activating the JNK/ERK Signaling Pathway [PDF]

BioMed Research International, 2015
Chlamydophila psittaci(C. psittaci) is a human zoonotic pathogen, which could result in severe respiratory disease. In the present study, we investigated the role and mechanism of the type III secretion system (T3SS) ofC. psittaciin regulating the inflammatory response in host cells.C. psittaci-infected THP-1 cells were incubated with the specific T3SS
He, Qing-zhi, Zeng, Huai-cai, Huang, Yan, Hu, Yan-qun, Wu, Yi-mou   +4 more
openaire   +2 more sources

Type III chaperones & Co in bacterial plant pathogens: a set of specialized bodyguards mediating effector delivery

Frontiers in Plant Science, 2013
Gram-negative plant pathogenic bacteria possess a type III secretion system (T3SS) to inject bacterial proteins, called type III effectors (T3Es), into host cells through a specialized syringe structure. T3Es are virulence factors that can suppress plant
David eLohou, David eLohou, Fabien eLonjon, Fabien eLonjon, Stéphane eGenin, Stéphane eGenin, Fabienne eVailleau, Fabienne eVailleau, Fabienne eVailleau   +8 more
doaj   +1 more source

Structural Insights of Shigella Translocator IpaB and Its Chaperone IpgC in Solution

Frontiers in Cellular and Infection Microbiology, 2021
Bacterial Type III Secretion Systems (T3SSs) are specialized multicomponent nanomachines that mediate the transport of proteins either to extracellular locations or deliver Type III Secretion effectors directly into eukaryotic host cell cytoplasm ...
Mariana L. Ferrari, Mariana L. Ferrari, Spyridoula N. Charova, Philippe J. Sansonetti, Philippe J. Sansonetti, Philippe J. Sansonetti, Efstratios Mylonas, Anastasia D. Gazi, Anastasia D. Gazi, Anastasia D. Gazi   +9 more
doaj   +1 more source

Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7 [PDF]

, 2009
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of <i>Escherichia ...
Layton, Abigail, Stevens, M. P., Tree, J.J., Stevens, Mark P, Tree, J. J., Roe, A. J., McInally, C., Roe, Andrew J, Tree, Jai J, Wang, Dai, Elofsson, M., Houghton, I., Mahajan, A., Stevens, M.P., Gally, D. L., Roe, A.J., Wang, D., Gally, D.L., Layton, A., Elofsson, Mikael,, McInally, Carol, Houghton, Irene, Mahajan, Arvind, Gally, David L   +23 more
core   +1 more source

An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

Frontiers in Cellular and Infection Microbiology, 2018
Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with
Jessica M. Morgan, Hanh N. Lam, Jocelyn Delgado, Justin Luu, Sina Mohammadi, Ralph R. Isberg, Helen Wang, Victoria Auerbuch   +7 more
doaj   +1 more source

LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution

Nature Communications, 2020
The type III secretion system (T3SS) of bacteria can be used to inject cargo into eukaryotic cells but its lack of target specificity is a disadvantage.
Florian Lindner, Bailey Milne-Davies, Katja Langenfeld, Thorsten Stiewe, Andreas Diepold   +4 more
doaj   +1 more source

The type III secreted protein BspR regulates the virulence genes in Bordetella bronchiseptica. [PDF]

PLoS ONE, 2012
Bordetella bronchiseptica is closely related with B. pertussis and B. parapertussis, the causative agents of whooping cough. These pathogenic species share a number of virulence genes, including the gene locus for the type III secretion system (T3SS ...
Jun Kurushima, Asaomi Kuwae, Akio Abe
doaj   +1 more source