Results 51 to 60 of about 27,042,650 (190)

A ParDE toxin–antitoxin system is responsible for the maintenance of the Yersinia virulence plasmid but not for type III secretion-associated growth inhibition

Frontiers in Cellular and Infection Microbiology, 2023
Many Gram-negative pathogens utilize the type III secretion system (T3SS) to translocate virulence-promoting effector proteins into eukaryotic host cells.
Saskia Schott, Robina Scheuer, Francesca Ermoli, Timo Glatter, Elena Evguenieva-Hackenberg, Andreas Diepold   +5 more
doaj   +1 more source

Secretin interactions in the type II secretion system [PDF]

, 2012
PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
core   +2 more sources

Genome-wide Investigation of Vibrio parahaemolyticus Type III Secretion System-1 Regulation and Chitin Metabolism

, 2022
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans following the consumption of contaminated seafood, and is a consequential organism for aquaculture and human health.
Getz, Landon John
core  

Aeromonas salmonicida type III secretion system-effectors-mediated immune suppression in rainbow trout (Oncorhynchus mykiss). [PDF]

, 2017
Aeromonas salmonicida subsp. salmonicida, the etiologic agent of furunculosis, is a major pathogen in aquaculture. Together with other pathogens, it is characterized by the presence of a type 3 secretion system (T3SS).
Origgi, Francesco, Segner, Helmut, Benedicenti, Ottavia, Frey, Joachim, Sattler, Ursula, Wahli, Thomas, Frey J, Benedicenti O, Sattler U, Origgi FC, Segner, H, Frey, J, Wahli, T, Segner H, Benedicenti, O, Origgi, F, Sattler, U, Wahli T   +17 more
core   +2 more sources

A Novel Periplasmic Protein, VrpA, Contributes to Efficient Protein Secretion by the Type III Secretion System in Xanthomonas spp.

Molecular Plant-Microbe Interactions, 2015
Efficient secretion of type III effector proteins from the bacterial cytoplasm to host cell cytosol via a type III secretion system (T3SS) is crucial for virulence of plant-pathogenic bacterium.
Xiaofeng Zhou, Xiufang Hu, Jinyun Li, Nian Wang   +3 more
doaj   +1 more source

New players in the same old game: a system level in silico study to predict type III secretion system and effector proteins in bacterial genomes reveals common themes in T3SS mediated pathogenesis [PDF]

BMC Research Notes, 2013
Abstract Background Type III secretion system (T3SS) plays an important role in virulence or symbiosis of many pathogenic or symbiotic bacteria [CHM 2:291–294, 2007; Physiology (Bethesda) 20:326–339, 2005]. T3SS acts like a tunnel between a bacterium and its host through which the bacterium injects ‘effector’ proteins
Sadarangani, Vineet, Datta, Sunando, Arunachalam, Manonmani   +2 more
openaire   +2 more sources

Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in a Pseudomonas aeruginosa Crc-Defective Mutant

, 2023
Pseudomonas aeruginosa is a ubiquitous nosocomial opportunistic pathogen that harbors many virulence determinants. Part of P. aeruginosa success colonizing a variety of habitats resides in its metabolic robustness and plasticity, which are the basis of ...
Hernando-Amado, Sara, Reales-Calderón, José Antonio, Sara Hernando-Amado, Juan F. Linares, Fernando Corona, Martínez, José L., Jose Antonio Reales-Calderón, Linares, Juan F., Teresa Gil-Gil, Gil-Gil, Teresa, Cuesta, Trinidad, Corona, Fernando, José L. Martínez, Trinidad Cuesta   +13 more
core   +1 more source

A Salmonella Virulence Factor Activates the NOD1/NOD2 Signaling Pathway

mBio, 2011
The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
A. Marijke Keestra, Maria G. Winter, Daisy Klein-Douwel, Mariana N. Xavier, Sebastian E. Winter, Anita Kim, Renée M. Tsolis, Andreas J. Bäumler   +7 more
doaj   +1 more source

Activation of the Yersinia type III secretion system induces large-scale spatial reorganization of chromosomal and virulence plasmid DNA

Cell Reports
Summary: The type III secretion system (T3SS) is used by Gram-negative bacteria, including important pathogens, to manipulate eukaryotic cells by injecting effector proteins. Type III secretion and bacterial physiology are tightly interconnected. Notably,
Francesca Ermoli, Christoph Spahn, Ismath Sadhir, Helge B. Bode, Andreas Diepold   +4 more
doaj   +1 more source

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

Nature Communications, 2019
Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different ...
Dorothy D. Majewski, Liam J. Worrall, Chuan Hong, Claire E. Atkinson, Marija Vuckovic, Nobuhiko Watanabe, Zhiheng Yu, Natalie C. J. Strynadka   +7 more
doaj   +1 more source