Results 21 to 30 of about 27,042,650 (190)

Pilotins are mobile T3SS components involved in assembly and substrate specificity of the bacterial type III secretion system [PDF]

Molecular Microbiology, 2022
Abstract In animal pathogens, assembly of the type III secretion system injectisome requires the presence of so-called pilotins, small lipoproteins that assist the formation of the secretin ring in the outer membrane.
Stephan Wimmi, Moritz Fleck, Carlos Helbig, Corentin Brianceau, Katja Langenfeld, Witold G. Szymanski, Georgia Angelidou, Timo Glatter, Andreas Diepold   +8 more
openaire   +4 more sources

Type III secretion system chaperones: a helping hand for secretion. [PDF]

Microbiology (Reading)
The type III secretion system (T3SS) is a virulence mechanism commonly used by Gram-negative bacterial pathogens to deliver virulence proteins, known as effectors, into infected cells.
Roepke KC, Galsworthy AJ, Agbamu A, Sheldon IC, Hocher A, Godlee C.   +5 more
europepmc   +3 more sources

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae. [PDF]

Mol Plant Pathol
ABSTRACT The pathogen Dickeya oryzae is responsible for soft rot disease in both monocotyledonous and dicotyledonous plants, resulting in substantial yield losses across a variety of important crops.
Lv M, Huang W, Meng Z, Fan X, Li P, Xu Z, Chen S, Chen X, Zhou J, Zhang L, Cheng Y, Zhuo T, Hu M.   +12 more
europepmc   +2 more sources

HrpS Is a Global Regulator on Type III Secretion System (T3SS) and Non-T3SS Genes in Pseudomonas savastanoi pv. phaseolicola [PDF]

Molecular Plant-Microbe Interactions®, 2018
The type III secretion system (T3SS) is the main machinery for Pseudomonas savastanoi and other gram-negative bacteria to invade plant cells. HrpR and HrpS form a hetero-hexamer, which activates the expression of HrpL, which induces all T3SS genes by binding to a ‘hrp box’ in promoters.
Jingru Wang, Xiaolong Shao, Yingchao Zhang, Yanan Zhu, Pan Yang, Jian Yuan, Tingting Wang, Chunyan Yin, Wei Wang, Sheng Chen, Haihua Liang, Xin Deng   +11 more
openaire   +4 more sources

Evolution of N-terminal mechanical lability as a determinant for Type III secretion. [PDF]

Protein Sci
Abstract Many Gram‐negative pathogens critically depend on the Type III secretion system (T3SS) to inject effector proteins into host cells for colonization. Because the channel of the T3SS is narrow (~2 nm), effectors must be unfolded for secretion.
DaPron KE, Plastow AM, Fink MR, Dzuba B, LeBlanc MA, Perkins TT, Tajkhorshid E, Sousa MC.   +7 more
europepmc   +2 more sources

SlyA Regulates Type III Secretion System (T3SS) Genes in Parallel with the T3SS Master Regulator HrpL in Dickeya dadantii 3937 [PDF]

Applied and Environmental Microbiology, 2012
ABSTRACT The hypersensitive response and pathogenicity ( hrp ) genes of Dickeya dadantii 3937 encode a type III secretion system (T3SS) which is essential for its full virulence. Previous studies of the T3SS regulation in D.
Lifang, Zou, Quan, Zeng, Haiping, Lin, Prasad, Gyaneshwar, Gongyou, Chen, Ching-Hong, Yang   +5 more
openaire   +2 more sources

Distribution and diversity of bacterial secretion systems across metagenomic datasets [PDF]

, 2012
Bacteria can manipulate their surrounding environment through the secretion of proteins into other living organisms and into the extracellular milieu. In Gram stain negative bacteria this process is mediated by different types of secretion systems from ...
Egan, Frank, O’Gara, Fergal, Barret, Matthieu, O'Gara, Fergal   +3 more
core   +2 more sources

Enhancing the Secretion Systems: Genetic Engineering of Super Bioagents for Effective Plant Disease Control. [PDF]

Biotechnol Bioeng
Genetic engineering (GE) overcomes BCA limits, enabling robust, scalable crop protection. “Super Bioagents” (SBs) use optimized SSs to enhance bioactive molecule delivery. Optimizing SSs enhance precise, sustainable effector deployment for stable disease suppression. SBs use microbiome‐informed design for scalable, next‐gen sustainable crop protection.
Asemoloye MD.
europepmc   +2 more sources

Synthesis and structure–activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS) [PDF]

Bioorganic & Medicinal Chemistry, 2015
The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in vivo pathogenicity. One such virulence factor is the type III secretion system (T3SS), which plays a critical role in the establishment and ...
John D, Williams, Matthew C, Torhan, Venugopal R, Neelagiri, Carson, Brown, Nicholas O, Bowlin, Ming, Di, Courtney T, McCarthy, Daniel, Aiello, Norton P, Peet, Terry L, Bowlin, Donald T, Moir   +10 more
openaire   +2 more sources

Edwardsiella ictaluri type III secretion system (T3SS) effector EseN is a phosphothreonine lyase that inactivates ERK1/2 [PDF]

Diseases of Aquatic Organisms, 2018
EseN is a type III secretion system (T3SS) effector that is encoded on the Edwardsiella ictaluri chromosome and is homologous to a family of T3SS effector proteins with phosphothreonine lyase (PTL) activity, including OspF from Shigella and SpvC from Salmonella.
Lidiya P, Dubytska, Ronald L, Thune
openaire   +2 more sources