Results 151 to 160 of about 5,135,675 (370)
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu+15 more
wiley +1 more source
Heating conversion of indole-3-carbinol into N-substituted oligomers with anti-melanoma effect
Cruciferous vegetables (CVs) are globally consumed with some health benefits believed to arise from indole-3-carbinol (I3C), a labile phytochemical liberated from indole glucosinolates, but few reports describe the effect of cooking on I3C reactions ...
Jia Cheng Qian+3 more
doaj
AN EXPERIMENTAL STUDY OF THE EFFICACY OF GAUZE FACE MASKS
W. H. Kellogg, Grace MacMillan
openalex +2 more sources
INTRAVITREAL INJECTION OF PENICILLIN: STUDY ON THE LEVELS OF CONCENTRATION REACHED AND THERAPEUTIC EFFICACY [PDF]
Arnold Sorsby, J. Ungar
openalex +1 more source
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair+17 more
wiley +1 more source
TITE-STEIN: Time-to-event Simple Toxicity and Efficacy Interval Design to Accelerate Phase I/II Trials [PDF]
Oncology dose-finding trials are shifting from identifying the maximum tolerated dose (MTD) to determining the optimal biological dose (OBD), driven by the need for efficient methods that consider both toxicity and efficacy. This is particularly important for novel therapies, such as immunotherapies and molecularly targeted therapies, which often ...
arxiv
Comparative Efficacy of Hypnotics: A Self-Controlled, Self-Recorded Clinical Trial in Neurotic Patients [PDF]
Edward Hare
openalex +1 more source
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
Experiments on the efficacy of Perkins' steam boilers, or circulators [PDF]
A. D. Bache
openalex +1 more source