Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla+4 more
wiley +1 more source
Chauhan Weighted Trajectory Analysis of Combined Efficacy and Safety Outcomes for Risk-Benefit Analysis. [PDF]
Chauhan U, Mackey D, Mackey JR.
europepmc +1 more source
Experiments to Determine the Efficacy of the Different Constituents of Haffkine's Plague Prophylactic [PDF]
C. B. Stewart
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Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel+4 more
wiley +1 more source
The influence of exercise self-efficacy and gender on the relationship between exercise motivation and physical activity in college students. [PDF]
Sheng J, Ariffin IAB, Tham J.
europepmc +1 more source
Establishment and biological characterization of radioresistant colorectal cancer cell lines
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu+10 more
wiley +1 more source
Neurosurgical management for chronic and end-of-life pain in children: A systematic review. [PDF]
Abdelmageed S+7 more
europepmc +1 more source
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik+3 more
wiley +1 more source
Efficacy or effectiveness? [PDF]
M. H. Pittler, Edzard Ernst
openaire +3 more sources
Self-compassion, academic stress, and academic self-efficacy among undergraduate nursing students: a cross-sectional, multi-center study. [PDF]
Nazari AM+3 more
europepmc +1 more source