Results 81 to 90 of about 8,363,616 (384)

Efficacy and safety of recombinant human activated protein C for severe sepsis.

New England Journal of Medicine, 2001
BACKGROUND Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties.
G. R. Bernard, J. L. Vincent, P. Laterre, S. LaRosa, J. Dhainaut, A. Lopez-Rodriguez, J. Steingrub, G. E. Garber, J. Helterbrand, E. W. Ely, C. J. Fisher   +10 more
semanticscholar   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes

BMC Pulmonary Medicine, 2019
Background The respiratory system is exposed to various allergens via inhaled and intranasal routes. Murine models of allergic lung disease have been developed to clarify the mechanisms underlying inflammatory responses and evaluate the efficacy of novel
Dong Im Kim, Mi-Kyung Song, Kyuhong Lee
doaj   +1 more source

Dispersant Efficacy and Effectiveness [PDF]

, 2011
Dispersants have been researched extensively and used for oil spill mitigation for more than 40 years, yet there are opportunities to enhance our understanding, including with respect to their long term fate and effects and how to optimize dispersant use.
Coolbaugh, Thomas, McElroy, Amy
core   +1 more source

Fear of Crime, Incivilities, and Collective Efficacy in Four Miami Neighborhoods [PDF]

, 2013
Purpose: Extant literature indicates that individual perceptions of collective efficacy and incivilities are important in explaining fear of crime. These studies, however, often implicitly assume that the relationships between key variables do not differ
Solomon, Shellie E., Swatt, Marc L., Uchida, Craig D., Varano, Sean P.   +3 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Relationship of core self-evaluations traits--self-esteem, generalized self-efficacy, locus of control, and emotional stability--with job satisfaction and job performance: a meta-analysis.

Journal of Applied Psychology, 2001
This article presents meta-analytic results of the relationship of 4 traits--self-esteem, generalized self-efficacy, locus of control, and emotional stability (low neuroticism) with job satisfaction and job performance.
T. Judge, J. Bono
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Optimization of Inorganic Ceramic Membrane Filtration Process for Tea Enzymes

Shipin gongye ke-ji
In order to enhance the clarity of tea enzymes while maximizing the preservation of their functional components during the clarification process, this experiment utilized tea enzymes derived from summer and autumn tea fermentation as the primary material.
Chunyan LI, Fuxiao WEI, Yu WANG, Chaoju ZHANG, Tiantian XU, Daoping WANG   +5 more
doaj   +1 more source