Results 81 to 90 of about 6,699,838 (364)
Legal Theory, 2019 ABSTRACT“A legal system exists,” Joseph Raz claims, “if and only if it is in force.” By this he means to suggest that the efficacy of law—that is, its capacity to control the population to which it applies—is necessary for its identity as such. Despite widespread recognition that efficacy is a condition of the existence of law, however, little time has
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
Science, 2018 Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade ...
Vyara Matson +7 more
semanticscholar +1 more source
Self-efficacy and degree choice among sports coaching and physical education students [PDF]
, 2004 Report of a CELT project on supporting students through innovation and researchThis study investigates self-efficacy perceptions among Level 1 Sports students and Level 1 Physical Education (P.E.) students.
Horrell, Andrew +3 more
core
Peach Kernel Oil Modulates Lipid Metabolism Disorder in ApoEa CRISPR/Cas9 Gene‐Disrupted Zebrafish
Food FrontiersDue to today's unhealthy eating habits, such as high‐fat diets (HDs), people's bodies are in a sub‐healthy or unhealthy state, in which lipid disorders are a major cause of cardiovascular disease.
Lei Xia +14 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Dupilumab Efficacy and Safety in Moderate‐to‐Severe Uncontrolled Asthma
New England Journal of Medicine, 2018 BACKGROUND Dupilumab is a fully human anti–interleukin‐4 receptor α monoclonal antibody that blocks both interleukin‐4 and interleukin‐13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma.
M. Castro +26 more
semanticscholar +1 more source
The stroke self-efficacy questionnaire: measuring individual confidence in functional performance after stroke [PDF]
, 2008 Aims and objectives. The aim was to develop a questionnaire for use by practitioners working in stroke care to measure self-efficacy judgements in specific domains of functioning relevant to individuals following stroke. Background.
Cecily Partridge +5 more
core +1 more source
Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes
BMC Pulmonary Medicine, 2019 Background The respiratory system is exposed to various allergens via inhaled and intranasal routes. Murine models of allergic lung disease have been developed to clarify the mechanisms underlying inflammatory responses and evaluate the efficacy of novel
Dong Im Kim, Mi-Kyung Song, Kyuhong Lee
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source