Results 101 to 110 of about 13,947,017 (382)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Analysis and standardization of coal chemical wastewater treatment and reuse systems

Water Cycle
To meet the practical needs of classified collection, graded treatment, and quality recycling of coal chemical wastewater, and in accordance with the standardization requirements of wastewater resource utilization, the Standardization Administration of ...
Jialin Liu, Xue Bai, Yan Bai
doaj   +1 more source

Labour efficiency on-farm [PDF]

, 2007
End of project reportImprovements in milking efficiency have a greater influence than any other aspect of the dairy farmers work on overall farm labour inputs (Whipp, 1992).
Boyle, Laura, Gleeson, David E, Kinsella, J., McNamara, John G., Mee, John F, O'Brien, Bernadette, O'Donovan, K., Ruane, D.   +7 more
core  

Spectral Efficiency and Energy Efficiency of OFDM Systems: Impact of Power Amplifiers and Countermeasures [PDF]

, 2013
In wireless communication systems, the nonlinear effect and inefficiency of power amplifier (PA) have posed practical challenges for system designs to achieve high spectral efficiency (SE) and energy efficiency (EE).
Ho, Chin Keong, Joung, Jingon, Sun, Sumei   +2 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

THE THERMAL EFFICIENCY OF STEAM ENGINES [PDF]

, 1899
R. H. Thurston
openalex   +2 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

A unified STR profiling system across multiple species with whole genome sequencing data

BMC Bioinformatics, 2019
Background Short tandem repeats (STRs) serve as genetic markers in forensic scenes due to their high polymorphism in eukaryotic genomes. A variety of STRs profiling systems have been developed for species including human, dog, cat, cattle, etc ...
Yilin Liu, Jiao Xu, Miaoxia Chen, Changfa Wang, Shuaicheng Li   +4 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Assessing power-to-heat technologies for industrial electrification: A multi-criteria decision analysis approach

Energy Conversion and Management: X
Transitioning industrial heat systems from fossil fuels to electric-based solutions is crucial to mitigate climate change. This research identifies and evaluates various power-to-heat technologies, each technology contributes uniquely to the overarching ...
Arman Ashabi, Mohamed Mostafa, Andriy Hryshchenko, Ken Bruton, Dominic T.J. O’sullivan   +4 more
doaj   +1 more source