Results 111 to 120 of about 9,727,327 (310)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Elucidating the Role of Transcriptomic Networks and DNA Methylation in Collagen Deposition of Dezhou Donkey Skin

Animals
DNA methylation represents a predominant epigenetic modification with broad implications in various biological functions. Its role is particularly significant in the process of collagen deposition, a fundamental aspect of dermal development in donkeys ...
Xinrui Wang, Wei Ren, Yongdong Peng, Muhammad Zahoor Khan, Huili Liang, Yigang Zhang, Xiaotong Liu, Yinghui Chen, Xiyan Kou, Liyuan Wang, Changfa Wang, Yandong Zhan   +11 more
doaj   +1 more source

Azorean agriculture efficiency by PAR [PDF]

, 2010
The producers always aspire at increasing the efficiency of their production process. However, they do not always succeed in optimizing their production.
Mendes, Armando B., Noncheva, Veska, Silva, Emiliana   +2 more
core  

Efficiency in Multi-objective Games

, 2015
In a multi-objective game, each agent individually evaluates each overall action-profile on multiple objectives. I generalize the price of anarchy to multi-objective games and provide a polynomial-time algorithm to assess it.
AX Jiang, C Daskalakis, C Menger, D Blackwell, D Monderer, E Koutsoupias, F Patrone, G Gottlob, J Madeley, K Marx, LS Shapley, N Immorlica, RW Rosenthal, S Adam, S Aland, T Roughgarden, U Nadav, X Guo   +17 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efficiency of the dynamical mechanism

, 2004
The most extreme starbursts occur in galaxy mergers, and it is now acknowledged that dynamical triggering has a primary importance in star formation.
A. Heavens, B. Nikolic, B.G. Elmegreen, D. Block, D. Downes, D. Sanders, D. Zaritsky, D.A. Hunter, E. Barton, E. Emsellem, E. Telles, E.D. Skillman, F. Bournaud, F.I. Pelupessy, H. Wozniak, J. Braine, J. Brinchmann, J. Knapen, J. Köppen, J.C. Mihos, J.C. Mihos, K. Bekki, K. Sakamoto, N. Bergvall, N. Brosch, N. Katz, R. Buta, R.C. Kennicutt, R.C. Kennicutt   +28 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis

BMC Psychiatry
Background Systemic therapy (ST) is a psychotherapeutic intervention in complex human systems (both psychological and interpersonal). Cognitive behavioural therapy (CBT) is an established treatment for children and adolescents with mental disorders.
David Henry Seidel, Martina Markes, Ulrich Grouven, Claudia-Martina Messow, Wiebke Sieben, Marco Knelangen, Rieke Oelkers-Ax, Sebastian Grümer, Heike Kölsch, Mandy Kromp, Markus von Pluto Prondzinski   +10 more
doaj   +1 more source