Results 131 to 140 of about 5,038,638 (360)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Efficient Bailouts? [PDF]

open access: yesFederal Reserve Bank of Dallas, Globalization and Monetary Policy Institute Working Papers, 2012
We develop a quantitative equilibrium model of financial crises to assess the interaction between ex post interventions in credit markets and the buildup of risk ex ante. During a systemic crisis, bailouts relax balance sheet constraints and mitigate the severity of the recession.
openaire   +5 more sources

Where are the savings on my Energy Efficiency (EE) improvements?

open access: yes, 2006
Title from caption of PDF document (viewed Mar.

core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

THE EFFICIENCY OF THE SERVICE [PDF]

open access: yesAJN, American Journal of Nursing, 1912
n ...
openaire   +1 more source

Debunking myths about energy efficiency lighting for your home energy saving tips from the Ohio Department of Development's Office of Energy Efficiency.

open access: yes, 2006
Title from p. [1] of PDF document (viewed Mar. 20, 2006).; "Created: 1/9/2006..."--Document properties screen.; Designed to be printed on one sheet, front and back, and then folded into a pamphlet.; Harvested from the web on 3/21/06Discusses the pros and

core  

Ways to Reveal the Sources of Decrease in Equipment Use Efficiency [PDF]

open access: yes, 2012
The conceptual sample piece of efficiency index of equipment use the which reflects possibility of work complex assessment of the equipment at which such indexes of use as, readiness, capacity, exhausted articles quality, the cost price are considered is
Момот, Александр Иванович   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Elucidating the Role of Transcriptomic Networks and DNA Methylation in Collagen Deposition of Dezhou Donkey Skin

open access: yesAnimals
DNA methylation represents a predominant epigenetic modification with broad implications in various biological functions. Its role is particularly significant in the process of collagen deposition, a fundamental aspect of dermal development in donkeys ...
Xinrui Wang   +11 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

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