CD9‐association with PIP2 areas is regulated by a CD9 salt bridge
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi+2 more
wiley +1 more source
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
Measuring the efficiency of synthetic routes and transformations using vectors derived from similarity and complexity. [PDF]
Genheden S, Howell GP.
europepmc +1 more source
The Relation of Posture to Human Efficiency and the Influence of Poise upon the Support and Function of the Viscera [PDF]
JOEL E. GOLDTHWAIT
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
A systematic analysis of contemporary whole exome sequencing capture kits to optimise high-coverage capture of CCDS regions. [PDF]
López FV, Ashton JJ, Cheng G, Ennis S.
europepmc +1 more source
The Detecting Efficiency of the Electron Tube Amplifier [PDF]
E. O. Hulburt, G. Breit
openalex +1 more source
The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh+2 more
wiley +1 more source
Tactical and statistical analysis of spiking efficiency by type, zone and set phase in women's volleyball. [PDF]
Sitti K, Rangubhet KR.
europepmc +1 more source