Results 61 to 70 of about 2,742,827 (268)

Comparative effectiveness of disease-modifying therapies for highly active relapsing-remitting multiple sclerosis despite previous treatment – a systematic review and network meta-analysis

open access: yesBMC Neurology
Background Comparative assessments of all available disease-modifying therapies (DMTs) in patients with highly active relapsing-remitting multiple sclerosis (RRMS) are lacking, even though some of these DMTs are restricted to this MS subpopulation.
Michael Köhler   +7 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Surface Hardening of Machine Parts Using Nitriding and TiN Coating Deposition in Glow Discharge

open access: yesMachines, 2020
Surface hardening of machine parts substantially improves their performance. The best results are obtained when combined hardening consists of surface nitriding and subsequent deposition of hard coatings.
Alexander Metel   +4 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Solutions to uneven light distribution and measurement distance variation in optical-based food inspection: A review

open access: yesJournal of Agriculture and Food Research
The demand for high-efficiency quality control in the food industry has driven the adoption of emerging techniques such as spectroscopy and imaging. The spectral and imaging detection processes are subject to various interferences, which may affect the ...
Shaojin Ma   +3 more
doaj   +1 more source

Cost-efficient Nearly Zero-Energy Buildings [PDF]

open access: yesE3S Web of Conferences, 2019
The next level of energy performance of new buildings within the European Union will be the Nearly Zero-Energy Building (NZEB). A lot of work has been spent on pilot and demonstration buildings on this and also even higher energy performance levels ...
Erhorn-Kluttig Heike   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Reducing Air Pollution in Rural Areas with Hybrid Heat Pump Supported by Biomass Boiler

open access: yesEnergies
The widespread deployment of low-carbon technologies in households is increasing the need to reduce peak electricity demand on distribution grids. Air-source heat pumps (ASHPs) are efficient heating units, but their performance declines at low ambient ...
Jaka Bizjak   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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