Results 111 to 120 of about 4,271,872 (307)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Development of Cloud Application Efficiency Evaluation Criterion
, 2015 Using cloud computing allows to significantly improve the infrastructure support, reduce deployment time and Faster adapt to changes in load with periodic peaks.
Козачук, Андрій Валерійович +1 more
core
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
, 2023 Abstract The article develops a criterion for the effectiveness of the development of an industrial enterprise using a dynamic system of indicators, which allows you to measure the effectiveness of purposeful activities in dynamics and taking into account the development trends of a business entity.
openaire +1 more source
STRICT LIABILITY VS NEGLIGENCE: IS ECONOMIC EFFICIENCY A RELEVANT COMPARISON CRITERION?
, 2021 The efficiency criterion (the highest care level at the lowest accident cost) indisputably governs the comparison of performance between strict liability and negligence.
Mondello, Gérard
core
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
, 2010 The continuous investment in research and development, aimed at improving the utility and the efficiency of wireless communications networks, brings about a wealth of theoretical knowledge and practical engineering solutions. Remarkably. however,a widely
Akhtman, Yosef, Hanzo, Lajos
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Nauka ta progres transportu, 2009 A complex criterion of estimation of efficiency of the management system by the construction projects is developed in the article. It assumes the choice of administrative decisions on the basis of data of project realization statistics and a middle risk ...
O. L. Herasymova
doaj