Results 121 to 130 of about 4,271,872 (307)

National Action Plan for Energy Efficiency [PDF]

, 2006
This report presents policy recommendations for creating a national commitment to energy efficiency through gas and electric utilities, utility regulators, and partner ...
National Action Plan for Energy Efficiency (U.S.)
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improving Feature Extraction by Replacing the Fisher Criterion by an Upper Error Bound [PDF]

A lot of alternatives and constraints have been proposed in order to improve the Fisher criterion. But most of them are not linked to the error rate, the primary interest in many applications of classification. By introducing an upper bound for the error
Luebke, Karsten, Weihs, Claus
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Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Criterion estimation of efficiency of air defense of the state [PDF]

, 2012
В даній статті розглядається порядок формування критерію та проведення критерійної оцінки ефективності протиповітряної оборони за допомогою імітаційних методів моделювання бойових дій.В данной статье рассматривается порядок формирования критерия и ...
Є.Б. Смірнов, В.І. Ткаченко, V.I. Tkachenko, E.B. Smirnov, В.И. Ткаченко, Е.Б. Смирнов   +5 more
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Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

COMPETENCE AS CRITERION OF STUDENTS TRAINING EFFICIENCY IN RUSSIAN UNIVERSITIES

RUDN Journal of Russian History, 2014
The article analyzes the substance of the notions “competence” and “competency”. The authors draw the conclusion that professional competence is a multifactorial phenomenon.
S S Sinyutin, V A Borisov
doaj  

The efficiency is a single criterion for choosing the type of interaxle drive

, 2018
The efficiency is proposed as a single criterion for choosing the type of interaxle drive. Dependence of efficiency on road conditions is shown. On the basis of the proposed approach, the opportunity to select the type of interaxle drive by comparing the
Andrey V. Efimov, Marina V. Korchagina, Sergey O. Kireev   +2 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

METHOD OF CHOICE OF A TECHNICAL SYSTEM FOR PROJECT IMPLEMENTATION BASING UPON SITUATIONAL EFFICIENCY CRITERION

Contemporary Economy, 2014
This work demonstrates correlation between technical system efficiency criterion and complex system efficiency criterion in which the said technical system operates.
Valentyn Chimshir, Anna Chimshir
doaj