Results 111 to 120 of about 3,292,414 (307)

Model-based Design Evaluation of a Compact, High-Efficiency Neutron Scatter Camera

, 2017
This paper presents the model-based design and evaluation of an instrument that estimates incident neutron direction using the kinematics of neutron scattering by hydrogen-1 nuclei in an organic scintillator.
Brubaker, Erik, Mattingly, John, Steele, John, Weinfurther, Kyle   +3 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Analysis of healthcare resource allocation efficiency and improvement pathways in Guangxi based on fsQCA configuration perspective

Frontiers in Health Services
IntroductionDisparities in healthcare resource allocation present a significant challenge in China, particularly in underdeveloped western regions like Guangxi.
Shangyuhui Huang, Jingwen Liang, Lin Wan, Tao Jiang, Wuxiang Shi   +4 more
doaj   +1 more source

Tesla turbine efficiency evaluation [PDF]

, 2017
The Tesla bladeless turbine differs from traditional turbines by the mechanism of energy transfer to the working shaft. The turbine does not have blades and flaws that arise with such a technical solution. The turbine consists of a set of smooth discs in
Radchenko, R. V., Shutov, A. D., Радченко, Р. В., Шутов, А. Д.   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evaluation method of the innovation project global efficiency [PDF]

A complete system of indexes to evaluate the global efficiency of a new product development project must approach at least the following perspectives: the financial performances of the project; the project's value; the technical performances of the ...
Ciurea, Jeanina Biliana, Sipos, Gabriela Lucia   +1 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Reallocation of the Organization Forces by the Super Effective Model Despite the Limitations on Number and the Way of Transferring the Forces of Some Units [PDF]

Iranian Journal of Optimization, 2018
In this paper, the efficiency of the performance of some independent units of police organization was evaluated to optimize the total used inputs and the total produced outputs of each unit.
maryam khatibi, Bijan Rahmani parchikolaei   +1 more
doaj  

Cold-air performance of a 15.41-cm-tip-diameter axial-flow power turbine with variable-area stator designed for a 75-kW automotive gas turbine engine [PDF]

An experimental evaluation of the aerodynamic performance of the axial flow, variable area stator power turbine stage for the Department of Energy upgraded automotive gas turbine engine was conducted in cold air.
Kofskey, M. G., Mclallin, K. L., Wong, R. Y.   +2 more
core   +1 more source