Results 191 to 200 of about 3,292,414 (307)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Energy efficiency evaluation of construction projects using data envelopment analysis and Tobit regression. [PDF]

Sci Rep
Iqbal M, Ma J, Mushtaq Z, Ahmad N, Yousaf MZ, Tarawneh B, Khan W, Pushkarna M, Zaitsev I.   +8 more
europepmc   +1 more source

Application of Three-Stage DEA Model Combined with BP Neural Network in Microfinancial Efficiency Evaluation. [PDF]

Comput Intell Neurosci, 2022
Yang J, Li X, Mei J, Chen L.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Construction and application of the technical and tactical efficiency evaluation model for table tennis matches based on grey correlation. [PDF]

BMC Sports Sci Med Rehabil
Yin H, Zhou Y, Chen X, Zhou L.
europepmc   +1 more source

SCHC over LoRaWAN Efficiency: Evaluation and Experimental Performance of Packet Fragmentation. [PDF]

Sensors (Basel), 2022
Muñoz R, Saez Hidalgo J, Canales F, Dujovne D, Céspedes S.   +4 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Application of mathematical models on efficiency evaluation and intervention of medical institutions in China. [PDF]

BMC Health Serv Res
Tai Q, Wang Q, Li J, Dou N, Wu H.
europepmc   +1 more source

Technical Efficiency Evaluation of Primary Health Care Institutions in Shenzhen, China, and Its Policy Implications under the COVID-19 Pandemic. [PDF]

Int J Environ Res Public Health, 2023
Chen S, Li Y, Zheng Y, Wu B, Bardhan R, Wu L.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source