Results 51 to 60 of about 605,818 (269)
Efficient Automation of Index Pairs in Computational Conley Index Theory [PDF]
SIAM Journal on Applied Dynamical Systems, 2012 We present new methods of automating the construction of index pairs, essential ingredients of discrete Conley index theory. These new algorithms are further steps in the direction of automating computer-assisted proofs of semi-conjugacies from a map on a manifold to a subshift of finite type.
Rafael M. Frongillo, Rodrigo Treviño
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi +6 more
wiley +1 more source
Optimal eight-order three-step iterative methods for solving systems of nonlinear equations
Discrete and Continuous Models and Applied Computational ScienceIn this paper, we for the first time propose the extension of optimal eighth-order methods to multidimensional case. It is shown that these extensions maintained the optimality properties of the original methods.
Tugal Zhanlav, Khuder Otgondorj
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Seismic Upgrading of Existing Steel Buildings Built on Soft Soil Using Passive Damping Systems
Buildings, 2023 In regions prone to seismic activity, buildings constructed on soft soil pose a significant concern due to their inferior seismic performance. This situation often results in considerable structural damage, substantial economic loss, and increased risk ...
Masoud Ahmadi, Mehdi Ebadi-Jamkhaneh
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Efficiency Index for Binary Classifiers: Concept, Extension, and Application
Mathematics, 2023 Many metrics exist for the evaluation of binary classifiers, all with their particular advantages and shortcomings. Recently, an “Efficiency Index” (EI) for the evaluation of classifiers has been proposed, based on the consistency (or matching) and ...
Andrew J. Larner
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source