Results 61 to 70 of about 605,818 (269)

Some New Higher Order Weighted Newton Methods for Solving Nonlinear Equation with Applications

open access: yesMathematical and Computational Applications, 2019
Three new iterative methods for solving scalar nonlinear equations using weight function technique are presented. The first one is a two-step fifth order method with four function evaluations which is improved from a two-step Newton’s method having
Parimala Sivakumar, Jayakumar Jayaraman
doaj   +1 more source

An Optimal Derivative Free Family of Chebyshev–Halley’s Method for Multiple Zeros

open access: yesMathematics, 2021
In this manuscript, we introduce the higher-order optimal derivative-free family of Chebyshev–Halley’s iterative technique to solve the nonlinear equation having the multiple roots. The designed scheme makes use of the weight function and one parameter α
Ramandeep Behl   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

An Optimal Eighth-Order Derivative-Free Family of Potra-Pták’s Method

open access: yesAlgorithms, 2015
In this paper, we present a new three-step derivative-free family based on Potra-Pták’s method for solving nonlinear equations numerically. In terms of computational cost, each member of the proposed family requires only four functional evaluations per ...
Munish Kansal   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Improved King–Werner-Type Method Based on Cubic Interpolation: Convergence Analysis and Complex Dynamics

open access: yesAxioms
In this paper, we study the convergence and complex dynamics of a novel higher-order multipoint iteration scheme to solve nonlinear equations. The approach is based upon utilizing cubic interpolation in the second step of the King–Werner method to ...
Moin-ud-Din Junjua   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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