Results 111 to 120 of about 2,040,345 (311)
Governance Reform of German food safety regulation: Cosmetic or real? [PDF]
Discussion of institutional changes made by the German government in response to the emergence of the first cases of BSE in Germany in 2000. Due to the establishment of a large-scale private sector quality assurance scheme, regulation moved away from ...
Steiner, Bodo
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Incomplete Regulation, Competition and Entry in Increasing Returns to Scale Industries [PDF]
The paper analyzes the effects of liberalization in increasing returns to scale industries. It studies the optimal regulation of an incumbent competing with an unregulated strategic competitor, when public funds are costly.
Sara BIANCINI
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Efficiency optimization design of modular hybrid wide voltage regulating DC transformer
Diance yu yibiaoModular input series output parallel DC transformer has a wide application prospect in medium and low voltage DC distribution network. In order to solve the problem of low efficiency of DC transformer in wide voltage regulation range, the efficiency ...
CHEN Jialuo +5 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Application of Reward Regulation for an Increase of Work Efficiency
Huli yanjiu, 1995 In 1991 the regulation of fixed number of staff members and fixed quantity in work was carried out among the medical workers of our department.All those who overfulfilled their quota, were given encouragement or awards to overcome equalitarianism, which ...
张瑜
doaj
The government needs to go beyond the Green Deal if it is genuinely committed to making households more energy efficient [PDF]
, 2012 Dave Timms argues that the Green Deal will not by itself be enough to drive take-up of energy efficiency measures, particularly for the least energy efficient segment of UK’s housing stock; the private rented sector (PRS).
Timms, Dave
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source