Results 121 to 130 of about 2,040,345 (311)

Economic Regulation of Network Industries [PDF]

This report was commissioned by Treasury in February 1999 as an input into its ongoing work programme on the regulation of network industries. Network industries are characterised by long-lived investments and increasing returns to scale. This raises two
Brian Williamson, Yogita Mumssen
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Improving the efficiency of frequency regulation for High-Power diesel generators

Energy Conversion and Management: X
This article tackles the optimization of crankshaft rotation frequency regulators in high-power diesel generators. These generators play a crucial role in the energy efficiency of standalone cogeneration plants.
Shchasiana Arhun, Aleksandr Bogajevskiy, Andrii Hnatov, Nadezhda Kunicina   +3 more
doaj   +1 more source

Effectiveness and welfare impacts of alternative polices to address atmospheric pollution in urban road transport. [PDF]

n this paper we compare the effectiveness and welfare effects of alternative fuel efficiency, environmental and transport policies for a given urban area.
Proost, Stef, Van Dender, Kurt
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Genome-wide association study and haplotype analysis reveal novel candidate genes for resistance to powdery mildew in soybean

Frontiers in Plant Science
Powdery mildew disease (PMD) is caused by the obligate biotrophic fungus Microsphaera diffusa Cooke & Peck (M. diffusa) and results in significant yield losses in soybean (Glycine max (L.) Merr.) crops.
Guoqiang Liu, Guoqiang Liu, Yuan Fang, Xueling Liu, Xueling Liu, Jiacan Jiang, Jiacan Jiang, Guangquan Ding, Guangquan Ding, Yongzhen Wang, Yongzhen Wang, Xueqian Zhao, Xueqian Zhao, Xiaomin Xu, Xiaomin Xu, Mengshi Liu, Mengshi Liu, Yingxiang Wang, Yingxiang Wang, Cunyi Yang, Cunyi Yang   +20 more
doaj   +1 more source

Benchmarking and incentive regulation of quality of service: an application to the UK electricity distribution utilities [PDF]

Quality of service has emerged as an important issue in post-reform regulation of electricity distribution networks. Regulators have employed partial incentive schemes to promote cost saving, investment efficiency, and service quality.
Giannakis, D., Pollitt, M.G., T. Jamasb
core  

Assessing the significance of knockout cascades in metabolic networks

, 2012
Complex networks have been shown to be robust against random structural perturbations, but vulnerable against targeted attacks. Robustness analysis usually simulates the removal of individual or sets of nodes, followed by the assessment of the inflicted ...
Basler, Georg, Güell, Oriol, Nikoloski, Zoran, Sagués, Francesc, Serrano, M. Ángeles   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source