Results 121 to 130 of about 459,449 (308)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Efficient Algorithms Unlock Understanding of Clonal Evolution in Cancer. [PDF]

Blood Cancer Discov, 2022
Miller CA.
europepmc   +1 more source

Algorithms for Locating Facilities under Uncertainties [PDF]

, 2008
One of the main challenges in the area of discrete optimization is to find efficient and effective ways of solving problems that arise in day-to-day life. Traditionally, algorithms for such problems require complete knowledge of input parameters which is
Nagarajan, Chandrashekhar
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Communication-efficient algorithms for solving pressure Poisson equation for multiphase flows using parallel computers. [PDF]

PLoS One, 2022
Ghosh S, Lu J, Gupta V, Tryggvason G.
europepmc   +1 more source

Efficient Algorithms for All Port-Based Teleportation Protocols

PRX Quantum
Port-based teleportation (PBT) is a form of quantum teleportation in which no corrective unitary is required on the part of the receiver. Two primary regimes exist—deterministic PBT in which teleportation is always successful, but is imperfect, and ...
Adam Wills, Min-Hsiu Hsieh, Sergii Strelchuk   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Efficient Algorithms for VM Placement in Cloud Data Centers

, 2017
The virtual machine (VM) placement problem is a major issue in optimizing resource ulitization of cloud data centers. With the rapid development of cloud computing, efficient algorithms are needed to reduce the power consumption and save energy in data ...
Hong Shen, Hui Tian, Jiahuai Wu, Tian, H, Wu, J, Shen, H   +5 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source