The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Accelerated Variational PDEs for Efficient Solution of Regularized Inversion Problems. [PDF]
J Math Imaging Vis, 2020 Benyamin M +3 more
europepmc +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
An efficient solution method for the flexible and robust inventory-routing of red blood cells
Computers & industrial engineering, 2018 Fatemeh Jafarkhan, S. Yaghoubi
semanticscholar +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Mixed-Host Systems with a Simple Device Structure for Efficient Solution-Processed Organic Light-Emitting Diodes of a Red-Orange TADF Emitter. [PDF]
ACS Omega, 2020 Kumar M, Pereira L.
europepmc +1 more source
Efficient Relocation of Spectrum Incumbents [PDF]
Changes in technologies and in consumer demands have made prior radio spectrum allocations far from efficient. To address this problem the FCC has recently reallocated spectrum for more flexible use in bands that are partially occupied by incumbent ...
Peter Cramton +2 more
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Halogenated azobenzene acrylates: from efficient solution photoswitching to stable solid-state photochromic materials. [PDF]
Beilstein J Org ChemVachtlová M +10 more
europepmc +1 more source
Efficient inter-group competition and the provision of public goods [PDF]
We propose an intergroup competition scheme (ICS) to solve the free-riding problem in the public goods game. Our solution only requires knowledge of the group contributions, is budget balanced and with the right parameters a dominant strategy.
Danielle Merrett, Pablo Guillen
core