Results 301 to 310 of about 427,575 (339)
Some of the next articles are maybe not open access.
Transintestinal cholesterol efflux
Current Opinion in Lipidology, 2010Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role of the intestine in cholesterol transport.In recent
Astrid E, van der Velde +2 more
openaire +5 more sources
Current Opinion in Infectious Diseases, 1999
Bacterial genomes sequenced to date almost invariably contain genes apparently coding for multidrug efflux pumps, and the yeast genome contains more than 30 putative multidrug efflux genes. Thus it is not surprising that multidrug efflux is a major cause of intrinsic drug resistance in many microorganisms, and plays an even more prominent role in ...
H, Nikaido, H I, Zgurskaya
openaire +2 more sources
Bacterial genomes sequenced to date almost invariably contain genes apparently coding for multidrug efflux pumps, and the yeast genome contains more than 30 putative multidrug efflux genes. Thus it is not surprising that multidrug efflux is a major cause of intrinsic drug resistance in many microorganisms, and plays an even more prominent role in ...
H, Nikaido, H I, Zgurskaya
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2001
Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
openaire +2 more sources
Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
openaire +2 more sources
Biochemical Pharmacology, 2000
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire +2 more sources
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
openaire +2 more sources
Bacterial efflux systems and efflux pumps inhibitors
Biochimie, 2005It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
openaire +2 more sources
Extratubular efflux and nephropathy
Acta Pathologica Japonica, 1984The extratubular efflux of periodic acid‐Schiff (PAS) positive material is used as a histological indicator of intrarenal reflux, and correlation of the PAS positive material and interstitial as well as glomerular changes were analyzed in 114 surgical specimens consisting of renal calculi, hydronephrosis, vesicoureteral reflux, and others.
H, Shigematsu, S, Murakami, B, Akikusa
openaire +2 more sources
Genetics of Cholesterol Efflux
Current Atherosclerosis Reports, 2012Plasma levels of high-density lipoprotein cholesterol (HDL-C) show an inverse association with coronary heart disease (CHD). As a biological trait, HDL-C is strongly genetically determined, with a heritability index ranging from 40 % to 60 %. HDL represents an appealing therapeutic target due to its beneficial pleiotropic effects in preventing CHD ...
Iulia, Iatan +4 more
openaire +2 more sources
Strophanthidin-induced sodium efflux
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1976The external cation dependence of a strophanthidin-induced Na efflux in dialysed axons was examined. In the presence of strophanthidin the replacement of external Na with choline produced no appreciable changes in Na efflux, whereas the replacement of external Na with Mg brought about a large and reversible reduction.
L, Beaugé, L J, Mullins
openaire +2 more sources
Angiotensin and norepinephrine efflux
European Journal of Pharmacology, 1969Abstract Rabbit aortae were equilibrated with labelled norepinephrine and the effects of various drugs on efflux of the catecholamine studied. Angiotensin amide (10 μg/ml) given at a rate of 0.18 ml/min increased norepinephrine efflux. Tyramine (100 μg/ml), cocaine (50 μg/ml), guanethidine (250 μg/ml), 0.25 and 0.4 M KCl, and acetylcholine (1 mg/ml ...
B K, Kiran, P A, Khairallah
openaire +2 more sources