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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2001
Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
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Efflux of free cholesterol (FC) continues even when cellular FC mass is unchanged. This reflects a recirculation of preformed FC between cells and extracellular fluids which has multiple functions in cell biology including receptor recycling and signaling as well as cellular FC homeostasis. Total FC efflux is heterogeneous.
C J, Fielding, P E, Fielding
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Biochemical Pharmacology, 2000
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
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Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps. Thus, within the group of primary active transporters, predominant in eucaryotes, six families belonging to the ATP-binding cassette ...
F, Van Bambeke, E, Balzi, P M, Tulkens
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Bacterial efflux systems and efflux pumps inhibitors
Biochimie, 2005It is now well established that bacterial resistance to antibiotics has become a serious problem of public health that concerns almost all antibacterial agents and that manifests in all fields of their application. Among the three main mechanisms involved in bacterial resistance (target modification, antibiotic inactivation or default of its ...
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Extratubular efflux and nephropathy
Acta Pathologica Japonica, 1984The extratubular efflux of periodic acid‐Schiff (PAS) positive material is used as a histological indicator of intrarenal reflux, and correlation of the PAS positive material and interstitial as well as glomerular changes were analyzed in 114 surgical specimens consisting of renal calculi, hydronephrosis, vesicoureteral reflux, and others.
H, Shigematsu, S, Murakami, B, Akikusa
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Genetics of Cholesterol Efflux
Current Atherosclerosis Reports, 2012Plasma levels of high-density lipoprotein cholesterol (HDL-C) show an inverse association with coronary heart disease (CHD). As a biological trait, HDL-C is strongly genetically determined, with a heritability index ranging from 40 % to 60 %. HDL represents an appealing therapeutic target due to its beneficial pleiotropic effects in preventing CHD ...
Iulia, Iatan +4 more
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Strophanthidin-induced sodium efflux
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1976The external cation dependence of a strophanthidin-induced Na efflux in dialysed axons was examined. In the presence of strophanthidin the replacement of external Na with choline produced no appreciable changes in Na efflux, whereas the replacement of external Na with Mg brought about a large and reversible reduction.
L, Beaugé, L J, Mullins
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Angiotensin and norepinephrine efflux
European Journal of Pharmacology, 1969Abstract Rabbit aortae were equilibrated with labelled norepinephrine and the effects of various drugs on efflux of the catecholamine studied. Angiotensin amide (10 μg/ml) given at a rate of 0.18 ml/min increased norepinephrine efflux. Tyramine (100 μg/ml), cocaine (50 μg/ml), guanethidine (250 μg/ml), 0.25 and 0.4 M KCl, and acetylcholine (1 mg/ml ...
B K, Kiran, P A, Khairallah
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Clinica Chimica Acta, 1973
Abstract Evidence is presented to suggest that enzyme protein retention in the cell depends on adequate adenosine triphosphate (ATP), and the behaviour of erythrocytes seems to support this. Further evidence suggests that retention is mediated within the cell and not simply by the cell membrane, which appears permeable to enzyme molecules.
J C, Sweetin, W H, Thomson
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Abstract Evidence is presented to suggest that enzyme protein retention in the cell depends on adequate adenosine triphosphate (ATP), and the behaviour of erythrocytes seems to support this. Further evidence suggests that retention is mediated within the cell and not simply by the cell membrane, which appears permeable to enzyme molecules.
J C, Sweetin, W H, Thomson
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Quantifying Cellular Cholesterol Efflux
2019Measuring cholesterol efflux involves the tracking of cholesterol movement out of cells. Cholesterol efflux is an essential mechanism to maintain cellular cholesterol homeostasis, and this process is largely regulated via the LXR transcription factors and their regulated genes, the ATP-binding cassette (ABC) cholesterol transporters ABCA1 and ABCG1 ...
Sabrina, Robichaud, Mireille, Ouimet
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Bacterial Efflux Pump Inhibitors
2008Infections caused by multidrug-resistant Gram-negative pathogens play a major role in the morbidity and mortality of hospitalized patients. The rise of resistance to current antibiotic therapies has made the discovery of new agents urgent. One of the major antibiotic resistance mechanisms utilized by more than 15 species of Gram-negative bacterial ...
Barbara J, Kamicker +7 more
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