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Inhibition of the multidrug resistance efflux pump
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1993An ATP-dependent efflux pump is found in the plasma membrane of certain multidrug resistant (MDR) cancer cells. Drug resistance is due to decreased intracellular drug levels that have been reduced to subcytotoxic concentrations. Inhibition of the MDR efflux pump with a reversal agent may 'trap' the cytotoxic drug inside the cell; thus, cellular drug ...
P W, Wigler, F K, Patterson
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Efflux pump activity in Enchytraeidae
2019Enchytraeids are ecologically relevant soil organisms, which play an important role in organic matter decomposition and soil bioturbation. They live in close contact with the pore water fraction of soil which makes them vulnerable to xenobiotics exposure.
Hackenberger Kutuzović, Davorka +3 more
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Multidrug-resistant bacteria are a major public health threat. MDR efflux pump overexpression and enzymatic changes are major antibiotic resistance mechanisms. Many drug and biofilm resistance strategies involve efflux pumps. Natural substrate and inhibitor identification is a new study. Efflux pump inhibition allows medication buildup inside bacterial
Neeraj Kumar +2 more
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Neeraj Kumar +2 more
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Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps
2014Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
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Cholestasis and the Role of Basolateral Efflux Pumps
Zeitschrift für Gastroenterologie, 2011ATP-dependent transport of biliary constituents, such as bile acids, reduced glutathione, and bilirubin glucuronosides across the hepatocyte canalicular membrane into bile represents the decisive driving force for the formation of biliary fluid. Functional characterization, cloning, and localization of hepatocellular transporter proteins has provided a
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Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria
Antibiotics, 2023Ruben Hartkoorn +2 more
exaly
Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
2022Pallavi Ahirrao +2 more
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