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Fighting back against bacterial resistance: Harnessing nanocarrier strategies to counter antibiotic efflux pumps

Next Materials
The global rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to public health, mainly driven by antibiotic efflux pumps that actively expel drugs from bacterial cells and lower intracellular antibiotic concentrations below
Kingsley Chimaeze Mbara, Yvonne Ngcobo, Betty Chivasa, Lethabo Masemola, Refilwe Mashamaite, Kopang Clemendi Mokhetho, Motsi Phuthi, Mandisa Mangisa, Poloko Stephen Kheoane, Shoeshoe Lydia Mokhele, Lorato Mmaoratwe Marakalala, Claudine Mbeb, Rosalinda Pepita Emeyene, Carmen Myrna Leonard, Vuyelwa Jacqueline Tembu, Clemence Tarirai   +15 more
doaj   +1 more source

Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity

BMC Microbiology, 2022
Background Contribution of efflux pumps in development of antimicrobial resistance has been largely addressed in Gram negative and to a much lesser extent in Gram positive bacteria.
Mohammad Hossein Sobhanipoor, Roya Ahmadrajabi, Hossein Hosseini Nave, Fereshteh Saffari   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efflux Pump-mediated Drug Resistance in Burkholderia

Frontiers in Microbiology, 2015
Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance.
Nicole L Podnecky, Katherine A Rhodes, Katherine A Rhodes, Herbert P Schweizer, Herbert P Schweizer   +4 more
doaj   +1 more source

Biochemistry of Bacterial Multidrug Efflux Pumps [PDF]

International Journal of Molecular Sciences, 2012
Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease ...
Kumar, Sanath, Varela, Manuel F.
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

mBio, 2016
For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment ...
Michelle M. C. Buckner, Jessica M. A. Blair, Roberto M. La Ragione, Jane Newcombe, Daniel J. Dwyer, Alasdair Ivens, Laura J. V. Piddock   +6 more
doaj   +1 more source

Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis. [PDF]

PLoS ONE, 2013
BACKGROUND: Efflux systems are involved in multidrug resistance in most Gram-negative non-fermentative bacteria. We have chosen Burkholderia thailandensis to dissect the development of multidrug resistance phenotypes under antibiotic pressure ...
Fabrice Vincent Biot, Mélanie Monique Lopez, Thomas Poyot, Fabienne Neulat-Ripoll, Sabrina Lignon, Arnaud Caclard, François Michel Thibault, Andre Peinnequin, Jean-Marie Pagès, Eric Valade   +9 more
doaj   +1 more source

Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in Acinetobacter baumannii

Antibiotics, 2022
Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Christina Meyer, Kai Lucaβen, Stefanie Gerson, Kyriaki Xanthopoulou, Thorsten Wille, Harald Seifert, Paul G. Higgins   +6 more
doaj   +1 more source

The MRP family of drug efflux pumps [PDF]

Oncogene, 2003
The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this family have provided insights not only into cellular resistance mechanisms associated with natural product chemotherapeutic agents, antifolates and nucleotide analogs ...
Gary D, Kruh, Martin G, Belinsky
openaire   +2 more sources