Results 81 to 90 of about 375,784 (349)

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Medical Thoracoscopy: A Useful Diagnostic Tool for Undiagnosed Pleural Effusion

, 2022
Rajendra Prasad, Abhijeet Singh, Abhishek Agarwal, Rajiv Garg, S K Verma, Nuzhat Husain   +5 more
openalex   +1 more source

Enabling Long Term, Shelf‐Stable Perovskite Solar Cells: Alumina Barriers to Protect Perovskite Devices from Moisture and Oxygen

Advanced Energy Materials, EarlyView.
This study reports a packaging strategy for perovskite photovoltaic devices using atomic layer deposition (ALD) of aluminum oxide. Through optimization of deposition temperature and oxidant chemistry, researchers develop a 50 nm barrier layer with superior water vapor (WVTR) and oxygen transmission rates (OTR).
Melissa A. Davis, Kelly Schutt, Duong Nguyen Minh, Xinwen Zhang, Chenchao Xie, Ross A. Kerner, Tianran Liu, Matthew O. Reese, Laura T. Schelhas, Michael D. Kempe, Axel F. Palmstrom, Joseph M. Luther   +11 more
wiley   +1 more source

Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology

Modern Pathology, 2015
Although most mesotheliomas present with pleural effusions, it is controversial whether mesothelioma can be diagnosed with confidence in effusion cytology.
J. Andrici, Amy Sheen, L. Sioson, Kathryn L Wardell, A. Clarkson, N. Watson, M. Ahadi, M. Farzin, C. Toon, A. Gill   +9 more
semanticscholar   +1 more source

MTCA‐Net: Multi‐Task Cascade Analysis Network for Real‐Time Sperm Quality Analysis

Advanced Intelligent Systems, EarlyView.
This article proposes MTCA‐Net, a multi‐task cascaded analysis network for real‐time sperm quality assessment in intracytoplasmic sperm injection. The framework integrates detection, tracking, and segmentation modules to jointly analyze sperm morphology and motility.
Jiajin Li, Wenwen Sun, Jun He, Xinyu Fan, Xuecheng Ge, Fengya Lu, Yadan Wang, Yi Wang, Zhiguo Zhang, Qibing Wu, Jinhua Zhou   +10 more
wiley   +1 more source

Fluid Overload-Associated Large B-Cell Lymphoma Presenting as Isolated Pleural Effusion

Hematology Reports
Primary effusion-based lymphomas are uncommon and may pose significant diagnostic challenges. Fluid overload-associated large B-cell lymphoma is a recently recognized entity in the 5th edition of the World Health Organization Classification of ...
Kevin Leeper, Lauren Borecky, Mojtaba Akhtari, Jun Wang   +3 more
doaj   +1 more source

Identifying Malignant Pleural Effusion by A Cancer Ratio (Serum LDH: Pleural Fluid ADA Ratio)

Lung, 2015
AimWe studied the diagnostic potential of serum lactate dehydrogenase (LDH) in malignant pleural effusion.MethodsRetrospective analysis of patients hospitalized with exudative pleural effusion in 2013.ResultsSerum LDH and serum LDH: pleural fluid ADA ...
Akash Verma, J. Abisheganaden, Richard W. Light   +2 more
semanticscholar   +1 more source

Redistributive land reforms, agricultural productivity, and structural change: New cross‐national evidence

American Journal of Agricultural Economics, EarlyView.
Abstract Large‐scale land reforms constitute a substantial redistribution of wealth and reallocation of agricultural land, which is a major form of asset and production input in developing countries. While land redistribution (from the rich to the poor) remains a highly controversial issue, extensive evidence on its effect is limited.
Devashish Mitra, Abdulaziz B. Shifa, Lan Anh Tong, Mehmet A. Ulubasoglu   +3 more
wiley   +1 more source