Results 101 to 110 of about 12,119 (270)

Edible Fungus Compound Cordycepin Protects Against Acetaminophen‐Induced Liver Injury

Journal of Clinical Laboratory Analysis, EarlyView.
This study demonstrates that pretreatment with cordycepin (COR) effectively protects against acetaminophen (APAP)‐induced acute liver injury in mice. COR mitigates liver damage by exerting strong antioxidant, anti‐inflammatory, and anti‐apoptotic effects through the modulation of ER proteostasis, HIF‐1, and PPAR signaling networks.
Chunjin Fu, Shuyu Li, Shengnan Shen, Chengchao Xu, Jingjing Liao, Na Lin   +5 more
wiley   +1 more source

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation [PDF]

, 2014
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures
Salvadori L, De Gregorio, Fabiola, A. Zolin, Guido, Stefano, Villella, Valeria R., Angela Sepe (663715), Zolin, Anna, Carlo A. Leone, Pinna LA, Daniela De Stefano (131144), S. Esposito, Rosa GD, Andrea Venerando (460236), D. D. Stefano, Valeria R. Villella, Speranza Esposito (663714), Villella VR, Laura Salvadori (663717), Speranza Esposito, Antonella Tosco (214447), Anna Bossi (663721), A. Tosco, Sepe A, PETTOELLO MANTOVANI, MASSIMO, Stefano Guido, Valeria Raia (524374), F. . D. Gregorio, Esposito, Speranza, Zolin A, Pinna, Lorenzo A, Villella, Valeria R, Maiuri L, Maiuri MC, G. G. Kroemer, Venerando A, Carlo A Leone (663719), A. Bossi, M. Pettoello Mantovani, Maiuri, Maria C, Kroemer, Guido, Pettoello-Mantovani, Massimo, Anna Bossi, Gianni Bona (505628), A. Venerando, Sepe, Angela, M. C. Maiuri, Leone CA, Guido Kroemer (82802), Rosa Grassia, G. D. Rosa, Antonella Tosco, Pinna, Lorenzo A., Valeria R Villella (663713), Anna Zolin, Fabiola De Gregorio, L. A. Pinna, Mehta A, Gregorio FD, Raia V., C. A. Leone, Raia, Valeria, Venerando, Andrea, Fabiola De Gregorio (663716), Grassia R, G. Bona, PINNA, LORENZO, Anna Zolin (375161), L. Salvadori, Bossi, Anna, V. R. Villella, Maiuri, Luigi, Kroemer G, Gianni Bona, Salvadori, Laura, Massimo Pettoello-Mantovani (583212), Anil Mehta, Tosco A, Laura Salvadori, Anil Mehta (202506), A. Sepe, Tosco, Antonella, Maiuri, Maria C., Stefano DD, Mehta, Anil, Rosa Grassia (663718), R. Grassia, Esposito S, Luigi Maiuri, Bossi A, Stefano Guido (112114), De Stefano, Daniela, Massimo Pettoello Mantovani, A. Mehta, Giuseppe De Rosa (206289), S. Guido, De Rosa, Giuseppe, Grassia, Rosa, Guido S, Luigi Maiuri (663723), Lorenzo A Pinna (663722), Giuseppe De Rosa, Bona G, Maria C. Maiuri, Daniela De Stefano, L. Maiuri, V. Raia, Leone, Carlo A, Bona, Gianni, Valeria Raia, Angela Sepe, Maria C Maiuri (663720), Guido Kroemer, Leone, Carlo A.   +112 more
core   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

EGCG induces cytosolic vacuolization.

, 2013
(A) Morphological alterations of EGCG-treated cells in serum-free medium were analyzed using light microscopy. Representative pictures of HepG2 cell treated with EGCG at indicated concentrations for 12 h (upper panel) or with 60 µM EGCG for indicated ...
Ting Duan (303958), Xin-Qiang Zhu (303962), Han-Ming Shen (284986), Fan Zhou (196667), Jing Zhou (168494), Ting Shen (303955), Nai-Di Yang (303951), Yin Shi (303960), Yin Zhang (303947)   +8 more
core   +1 more source

Integrated phytochemical and bioactivity profiling of Xanthium strumarium fruits from Korea and China: Implications for origin‐specific quality specification

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Geographic origin influences the phytochemical composition and biological activities of medicinal plant resources. Xanthium strumarium L. (XS) fruit is widely used in East Asian traditional medicine. However, current pharmacopeial standards primarily recognize Chinese‐derived material, despite the availability and traditional use of
Eunsu Song, Seung‐Min Oh, Jiyeon Chun, Jinah Hwang   +3 more
wiley   +1 more source

Effect of green tea catechins on body weight of Albino Wistar rats—An interventional study

National Journal of Physiology, Pharmacy and Pharmacology
Background: Obesity is a serious medical condition linked to metabolic syndrome, which puts individuals with obesity at risk for developing chronic diseases.
Shilpa A. V., Ambili Gopi Nair, Biju Bahuleyan   +2 more
doaj   +1 more source

Anticancer effects and molecular mechanisms of epigallocatechin-3-gallate

Integrative Medicine Research, 2014
Epigallocatechin-3-gallate (EGCG) is a type of catechin found in green tea. EGCG exhibits a variety of activities, including anti-inflammatory, antidiabetes, antiobesity, and antitumor. In this review, we focus on the antitumor effects of EGCG.
Kyoung-jin Min, Taeg Kyu Kwon
doaj   +1 more source

LC-ESI-MS/MS analysis of EGCG and NH₂-EGCG in the sera of mice treated with EGCG.

, 2016
(A) The ion current tracings of EGCG (left five tracings) and NH2-EGCG (right five tracings). BALB/c mice were intraperitoneally injected with 0.1 ml of EGCG (10 mM) or PBS. After injection for 10 or 30 min, the sera were collected.
Hirofumi Tachibana (210301), Hiroki Hamagami (2591236), Miho Chikazawa (433254), Hiroshi Tanaka (3087), Mai Furuhashi (2591239), Takahiro Shibata (433256), Mitsugu Akagawa (2064793), Yukinori Hatasa (1420450), Fumie Nakashima (1420447), Tatsuhiko Kondo (2591233), Koji Uchida (433258)   +10 more
core   +1 more source

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Synergistic Cytotoxicity of 5-Fluorouracil and Epigallocatechin-3-Gallate on Colorectal Cancer Stem Cell

Indonesian Journal of Cancer
Background: Colorectal cancer stem cells (CR-CSCs) derived from the HCT-116 cell line established human colon carcinoma cell line, validated with CD44+/CD133+.
Sugeng Ibrahim, Ignatius Riwanto, Catharina Suharti, Agung Putra, Selamat Budijitno   +4 more
doaj   +1 more source