Results 81 to 90 of about 31,205 (214)

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

A novel CsRNF‐CsHSF24‐CsF3′5′H2 module regulates epigallocatechin gallate biosynthesis in Camellia sinensis [PDF]

Plant J
Significance Statement While the biosynthetic pathway of tea catechins is well established, how post‐translational modifications govern this process has remained elusive. This study uncovers a regulatory module in which the E3 ubiquitin ligase CsRNF targets the transcription factor CsHSF24 for degradation, thereby controlling expression of the key ...
Yao X, Chen H, An H, Hu Y, Li T, Zhao Q, He T, Luo C, Zeng X, Lu L.   +9 more
europepmc   +2 more sources

Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5′-O-α-Glucopyranoside, a Novel EGCG Derivative

, 2018
Epigallocatechin gallate (EGCG) is a well-studied polyphenol with antioxidant effects. Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems.
Kyeonghwan Hwang, Sang Han, Eun-Mi Kim, Hyunsik Hwang, Doman Kim, Zubair Ratan, Junseong Park, Jae Cho, Eunji Kim   +8 more
core   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

EGCG blocks autophagic flux.

, 2013
(A) EGCG increases LC3-II and p62 protein level. HepG2 and MEF cells were treated with EGCG (60 µM) for indicated durations in full medium or in serum-free medium as indicated. Cell lysates were collected for western blot.
Ting Duan (303958), Xin-Qiang Zhu (303962), Han-Ming Shen (284986), Fan Zhou (196667), Jing Zhou (168494), Ting Shen (303955), Nai-Di Yang (303951), Yin Shi (303960), Yin Zhang (303947)   +8 more
core   +1 more source

Effects of Green Tea Supplementation on Chemoprevention at Different Stages of Carcinogenesis: A Systematic Review

Phytotherapy Research, EarlyView.
ABSTRACT Green tea catechins have chemopreventive potential; however, the clinical evidence remains inconsistent. This review evaluated the effects of supplementation with green tea derivatives on chemoprevention at different stages of carcinogenesis. PubMed, Embase, Web of Science, Scopus, the Cochrane Library, CINAHL, and Google Scholar were searched
Thaís Moreira Machado, Mariene Garcia Gomes, Érika Yuri Hirose Murahara, Ana Lúcia Chalhoub Chediac Rodrigues, Ariane Nadolskis Severine, Thais Giovaninni Roberto, Sinara Laurini Rossato   +6 more
wiley   +1 more source

Effect of green tea catechins on body weight of Albino Wistar rats—An interventional study

National Journal of Physiology, Pharmacy and Pharmacology
Background: Obesity is a serious medical condition linked to metabolic syndrome, which puts individuals with obesity at risk for developing chronic diseases.
Shilpa A. V., Ambili Gopi Nair, Biju Bahuleyan   +2 more
doaj   +1 more source

Protective Effect of Epigallocatechin‐3‐Gallate Against Fructose‐Induced Metabolic Associated Fatty Liver Disease in Mice by Regulating Ferroptosis and Autophagy via SIRT5

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) lacks effective pharmacological therapies and is strongly associated with excessive fructose consumption. Ferroptosis and autophagy dysregulation are increasingly recognized as key drivers of MAFLD progression.
Puyu Zhang, Cuiping Hou, Jiayi Liu, Bosheng Wang, Wenqi Liu, Xin Yang, Yubing Kang, Zequn Liu, Yalin Zhang, Zhuxi Liu, Yuhong Zhao, Lu Zhao   +11 more
wiley   +1 more source

Curcumin and EGCG: Potential cancer therapeutics [PDF]

, 2018
The incidence rates of colon and liver cancer differ dramatically between Northern and Southern India. It has been suggested that diet plays an important role in their occurrence. The consumption rates of curcumin and EGCG in these regions are diverse as
Suresh, Sandhya Varma
core   +3 more sources

Synergistic Cytotoxicity of 5-Fluorouracil and Epigallocatechin-3-Gallate on Colorectal Cancer Stem Cell

Indonesian Journal of Cancer
Background: Colorectal cancer stem cells (CR-CSCs) derived from the HCT-116 cell line established human colon carcinoma cell line, validated with CD44+/CD133+.
Sugeng Ibrahim, Ignatius Riwanto, Catharina Suharti, Agung Putra, Selamat Budijitno   +4 more
doaj   +1 more source