Results 1 to 10 of about 598,741 (306)

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells [PDF]

, 2015
Epidermal growth factor receptor (EGFR), member of the human epidermal growth factor receptor (HER) family, plays a critical role in regulating multiple cellular processes including proliferation, differentiation, cell migration and cell survival ...
Cardinali, Beatrice, FUSTAINO, VALENTINA, GIANNINI, Giuseppe, LALLI, CRISTIANA, Papoff, Giuliana, PRESUTTI, DARIO, Ruberti, Giovina, Samperna, Simone, Santini, Simonetta   +8 more
core   +15 more sources

EGFR Mutations Are Not All the Same: the Importance of Biomarker Testing in Non-small Cell Lung Cancer (NSCLC)—A Podcast Discussion Between Patients and Oncologists

Oncology and Therapy, 2023
This podcast, for healthcare professionals (HCPs), patients, and patient advocates, is a discussion among a panel of two patients (and co-founders of the patient advocacy group EGFR Resisters, https://egfrcancer.org/ ) and two oncologists.
Stephen V. Liu, Ivy B. Elkins, Jill Feldman, Sarah B. Goldberg   +3 more
doaj   +1 more source

Antiproliferative Activity of Lignans from Olea ferruginea: In Vitro Evidence Supported by Docking Studies

Frontiers in Bioscience-Landmark, 2023
Background: The aim of the current study was to investigate the anticancer potential of bioactive compounds isolated from the leaves of Olea ferruginea (O. ferruginea). Lignans from O.
Abdur Rauf, Umer Rashid, Aniqa Atta, Ishaq Khan, Zafar Ali Shah, Bushra Mobeen, Aneela Javed, Taghrid S. Alomar, Najla Almasoud, Saima Naz, Zubair Ahmad, Giovanni Ribaudo   +11 more
doaj   +1 more source

To evaluate the expression of EGFR and Ki-67 markers in oral squamous cell carcinoma and find its association with grading and staging of tumors

Journal of Dr. NTR University of Health Sciences, 2023
Background: In this study, we assessed the immunohistochemical expression of EGFR and Ki-67 in cases of oral squamous cell carcinoma and its association with grading and staging.
Sayali Gadre, Amit V. Varma, Garima Malpani, Kamal Malukani, Seema Jindal, Veena Verma   +5 more
doaj   +1 more source

Midazolam impedes lung carcinoma cell proliferation and migration via EGFR/MEK/ERK signaling pathway

Open Medicine, 2023
Non-small-cell lung cancer (NSCLC) is a dominating type of lung cancer with high morbidity and mortality. Midazolam has been reported to promote cell apoptosis in NSCLC, but the molecular mechanism of midazolam remains to be further explored.
Zhang Xiangchao, Han Zhe, Li Zhengjun, Wang Tao   +3 more
doaj   +1 more source

Epidermal growth factor receptor and STAT3 signal through KRAS have mutually opposite effects on CTEN

Journal of Biochemical and Clinical Genetics, 2021
Background: C-terminal tensin-like (CTEN) is a protein located at focal adhesions and has been reported to be an oncogene in the colon, breast, lung, and gastric cancer.
Saleh AlGhamdi, Salih Ibrahim, Kanwal Balloch, Darryl Jackson, Mohammad Ilyas   +4 more
doaj   +1 more source

A CRISPR Test for Rapidly and Sensitively Detecting Circulating EGFR Mutations

Diagnostics, 2020
The detection of EGFR mutations in circulating cell-free DNA can enable personalized therapy for cancer. The current techniques for detecting circulating EGFR mutations are expensive and time-consuming with moderate sensitivity.
Jen-Hui Tsou, Qixin Leng, Feng Jiang
doaj   +1 more source

Water-soluble pristine C60 fullerene attenuates acetaminophen-induced liver injury [PDF]

BioImpacts, 2019
Introduction: Oxidative stress has been suggested as the main trigger and pathological mechanism of toxic liver injury. Effects of powerful free radical scavenger С60 fullerene on rat liver injury and liver cells (HepG2 line) were aimed to be discovered.
Halyna Kuznietsova, Oksana Lynchak, Natalia Dziubenko, Tetyana Herheliuk, Yuriy Prylutskyy, Volodymyr Rybalchenko, Uwe Ritter   +6 more
doaj   +1 more source

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]

, 2015
Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T, Futter, CE, Hartley, JA, Hochhauser, D, Sorkin, A, Tomas, A, Vaughan, SO   +6 more
core   +1 more source

Decreasing Abdominal Circumference Is Associated with Improving Estimated Glomerular Filtration Rate (eGFR) with Lifestyle Modification in Japanese Men: A Pilot Study [PDF]

, 2011
The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined
Makino, Hirofumi, Miyatake, Nobuyuki, Numata, Takeyuki, Shikata, Kenichi   +3 more
core   +1 more source