Results 1 to 10 of about 785,489 (353)

Structure-based classification predicts drug response in EGFR-mutant NSCLC

Nature, 2021
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC)1–3.
Xiuning Le, J Kevin Hicks, Simon Heeke
exaly   +2 more sources

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management

Nature Reviews Clinical Oncology, 2022
Lecia V Sequist, Jessica J Lin
exaly   +2 more sources

Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

Signal Transduction and Targeted Therapy, 2019
Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor (EGFR) gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer (NSCLC).
Simon Vyse, Paul H Huang
exaly   +2 more sources

Real-world efficacy of postoperative adjuvant EGFR-TKI therapy for stage IA2-IA3 lung adenocarcinoma with high-risk pathological factors. [PDF]

World J Surg Oncol
Lu S, Liu C, Tao H, Zhao P, Luo J, Cong Z, Shen Y.   +6 more
europepmc   +3 more sources

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

Science Translational Medicine, 2011
Lecia V Sequist, Subba Digumarthy, Sara Akhavanfard   +2 more
exaly   +2 more sources

Evaluation of effect of epidermal growth factor receptor and vascular endothelial growth factor overexpression in survival of patients with glioblastoma multiforme [PDF]

Romanian Journal of Neurology, 2021
Background. In the central nervous system, glioblastoma multiforme (GBM) is one of the most important neoplasms in adults. Amplification of EGFR and VEGF genes is common in GBM. However, the role of overexpression of EGFR and VEGF in survival of patients
Babak Alijani, Hamid Saeidi Saedi, Hadi Hajizadeh Fallah, Ehsan Kazemnejad Leili, Adel Kiumarsi, Sasan Andalib   +5 more
doaj   +1 more source

Immunohistochemical Evaluation of EGFR Expression in Oral Dysplastic and Non-Dysplastic Leukoplakia [PDF]

Journal of Mashhad Dental School, 2023
Background: This study aimed to evaluate the expression of epidermal growth factor receptor (EGFR) in oral leukoplakia with and without dysplasia and normal mucosa by immunohistochemistry.Materials and Methods: In this study, 45 samples of oral ...
Nasrollah Saghravanian, Narges Ghazi, Abdollah Javan rashid, Mohammad Ebrahimi   +3 more
doaj   +1 more source

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Cancer Discovery, 2014
Cath Eberlein, M Raymond V Finlay, Richard A Ward   +2 more
exaly   +2 more sources

EGFR Mutations Are Not All the Same: the Importance of Biomarker Testing in Non-small Cell Lung Cancer (NSCLC)—A Podcast Discussion Between Patients and Oncologists

Oncology and Therapy, 2023
This podcast, for healthcare professionals (HCPs), patients, and patient advocates, is a discussion among a panel of two patients (and co-founders of the patient advocacy group EGFR Resisters, https://egfrcancer.org/ ) and two oncologists.
Stephen V. Liu, Ivy B. Elkins, Jill Feldman, Sarah B. Goldberg   +3 more
doaj   +1 more source

The Association between Glycated Hemoglobin and Estimated Glomerular Filtration Rate in Patients with Type 2 Diabetes based on the Hemoglobin Status [PDF]

Journal of Kerman University of Medical Sciences, 2021
Background:The aim of the present study was to examine the association between hemoglobin A1C (HbA1C( and eGFR in patients with type 2 diabetes (T2D). Methods:This cross-sectional study was conducted on 802 patients with T2D visiting Abu Reyhan Clinic of
Hamid Reza Samimagham, Mohammad Tamaddondar, Mitra Kazemi jahromi   +2 more
doaj   +1 more source