Results 221 to 230 of about 480,865 (305)

Dynamic clonal evolution of multiple bypass resistance mechanisms in <i>EGFR</i>-mutant lung adenocarcinoma: a case report. [PDF]

Front Oncol
Zhang Q, Yin X.
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

EGFR downstream signaling pathway in primary colorectal tumours and related metastatic sites: optimizing EGFR targeted treatment options.

, 2005
Bearzi I, Pierantoni C, related metastatic sites: optimizing EGFR targeted treatment o.p.t.i.o.n.s. Ann Oncol, Berardi R, Mandolesi A, Cascinu S. EGFR downstream signaling pathway in primary colorectal tumours, SCARTOZZI, MARIO, in stampa   +7 more
core  

RAF/MEK clamp inhibition with avutometinib and cetuximab in RAF1 S257L-mutated, anti-EGFR-refractory metastatic colorectal cancer in Gaucher's disease. [PDF]

Oncologist
Rose A, Rosenberg A, Grewal US, Brown TJ, Hornstein N.   +4 more
europepmc   +1 more source

Biological Resectability in Colorectal Liver Metastases: A Nomogram‐Based Continuous Risk Model to Define Borderline Disease

Annals of Gastroenterological Surgery, EarlyView.
KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Yuzo Umeda, Toshiharu Mitsuhashi, Tomokazu Fuji, Toru Kojima, Takeshi Koujima, Tatsuo Matsuda, Daisuke Satoh, Masaru Inagaki, Kosei Takagi, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source

Bronchoalveolar lavage fluid <i>EGFR</i> genotyping during bronchoscopic biopsy: concordance with tissue and additional molecular diagnostic yield in lung cancer. [PDF]

Transl Lung Cancer Res
Kim DK, Hur JY, Kim HJ, Kim IA, Lee JE, Chung C, Kang DH, Kim SY, Hong G, Park D, Lee KY.   +10 more
europepmc   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

Lower eGFR is independently associated with embolization‑requiring severe bleeding after percutaneous renal biopsy: a matched case-control study with dose-respons e analysis. [PDF]

Ren Fail
Xu Y, Huang W, Wu X, Lv H, Zhang Q, Lei W.   +5 more
europepmc   +1 more source

Systematic pathway‐level analysis defines conserved transcriptional divergence between primary lung tumors and cell line models

Animal Models and Experimental Medicine, EarlyView.
Lung cancer cell lines diverge substantially from primary tumors at the transcriptional level. Using single‐sample gene set enrichment analysis and L1‐penalized feature selection across TCGA‐LUAD and CCLE‐LUAD, we identified five Hallmark pathways (E2F targets, G2M checkpoint, IFNγ response, coagulation, and EMT) that discriminated primary tumors from ...
Pritam Bera, Rajesh Raju, Debodipta Das
wiley   +1 more source

Cystatin C-based eGFR discordance and mortality risk in adults with dysglycemia: Parallel cohort analyses of NHANES and CHARLS. [PDF]

Medicine (Baltimore)
Wei X, Liu M.
europepmc   +1 more source