Results 221 to 230 of about 478,784 (306)

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Novel Co-Occurrence of Germline <i>EGFR</i> p.V843I and Somatic <i>EGFR</i> Exon 19 Deletion in NSCLC: Insights into Reduced Sensitivity to EGFR-TKIs. [PDF]

Int J Mol Sci
Resen K, Melchior LC, Sørensen JB, Wadt KAW, Urbanska EM, Santoni-Rugiu E.   +5 more
europepmc   +1 more source

Beneficial Body Mass Index for Age‐Related Kidney Function in Males and Females

AGING MEDICINE, EarlyView.
The impact of BMI on age‐related kidney function decline is highly sex‐ and age‐dependent. Normal BMI (18.5–25 kg/m2) is associated with better age‐related kidney function in all‐aged males and females older than 45 years. ABSTRACT Objectives Kidney function declines with aging, leading to a high prevalence of age‐related disease.
Lu Wei, Yao Ma, Xueqi Chen, Xinran Ni, Yu Zhang, Bei Zhu, Qun Zhang, Weihong Zhao   +7 more
wiley   +1 more source

EGFR downstream signaling pathway in primary colorectal tumours and related metastatic sites: optimizing EGFR targeted treatment options.

, 2005
Bearzi I, Pierantoni C, related metastatic sites: optimizing EGFR targeted treatment o.p.t.i.o.n.s. Ann Oncol, Berardi R, Mandolesi A, Cascinu S. EGFR downstream signaling pathway in primary colorectal tumours, SCARTOZZI, MARIO, in stampa   +7 more
core  

The gamma-glutamyltransferase-to-estimated glomerular filtration rate composite index is associated with arterial stiffness: a cross-sectional secondary analysis of a health check-up population. [PDF]

Front Endocrinol (Lausanne)
Gu T, Li G, Li G, Gao P, Su Y, Li X, Zhao Z.   +6 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Discovery of Potent EGFR Inhibitors for Del19 and L858R/T790M Mutants Through Structure-Based Virtual Screening and Biological Evaluation. [PDF]

Chem Biol Drug Des
Xu T, Zhao Y, Chen M, Zuo L, Cai H, Liu Y, Liu C, Shi J.   +7 more
europepmc   +1 more source

Impact of Acute Functional Decline on Frailty and Mortality in Acutely Hospitalized Older Persons

AGING MEDICINE, EarlyView.
Older persons with acute functional decline are often severely frail. Male sex, cognitive impairment, diabetes mellitus type 2, cancer, hearing impairment, and nursing home living increase the risk of severe frailty or death and should be considered when person‐centered care is planned for hospitalized older people.
Ali Vahedi, Maria Eriksdotter, Hege Ihle‐Hansen, Torgeir Bruun Wyller, Anne Rita Øksengård, Brynjar Fure   +5 more
wiley   +1 more source

Co-Occurring EGFR L858R Mutation and HER2 Amplification in NSCLC Identified by Stepwise Molecular Profiling. [PDF]

Am J Case Rep
Kadyrbayeva R, Kaidarova D, Moldasheva A, Smagulova KK, Turkpenova I, Orazgalieva M, Ossikbayeva SO, Satbayeva E, Makarov V.   +8 more
europepmc   +1 more source

Biological Resectability in Colorectal Liver Metastases: A Nomogram‐Based Continuous Risk Model to Define Borderline Disease

Annals of Gastroenterological Surgery, EarlyView.
KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Yuzo Umeda, Toshiharu Mitsuhashi, Tomokazu Fuji, Toru Kojima, Takeshi Koujima, Tatsuo Matsuda, Daisuke Satoh, Masaru Inagaki, Kosei Takagi, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source