Results 181 to 190 of about 785,489 (353)

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro

Drug Design, Development and Therapy, 2020
Xinying Yu, 1 Fan Yang, 2 Hong Jiang, 3 Ling Fan 1 1Second Pediatric Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, People’s Republic of China; 2Third Neonatal Ward, Shengjing Hospital of ...
Yu X, Yang F, Jiang H, Fan L
doaj  

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, EarlyView.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency [PDF]

, 2017
Christopher M. Allan, Deanna Tran, Yiping Tu, Patrick J. Heizer, Lorraine C Young, Loren G. Fong, Anne P. Beigneux, Stephen G. Young   +7 more
openalex   +1 more source

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

New England Journal of Medicine, 2005
Susumu S. Kobayashi, T. Boggon, Tajhal Dayaram, P. Jänne, O. Kocher, M. Meyerson, B. Johnson, M. Eck, D. Tenen, B. Halmos   +9 more
semanticscholar   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

CMET-30. BRAIN METASTASES FROM EGFR-MUTATED NSCLC WHICH HAD ACQUIRED RESISTANCE TO EGFR-TKI. ~LESS-FREQUENT T790M AND PRESERVED RESPONSE TO OTHER TKIs~ [PDF]

, 2018
Toshihiko Iuchi, Tsukasa Sakaida, Yuzo Hasegawa, Yasushi Yoshida, Hironori Ashinuma, Satoko Mizuno, Taiki Setoguchi, Masato Shingoji   +7 more
openalex   +1 more source

Table S6 from Alterations in the Global Proteome and Phosphoproteome in Third Generation EGFR TKI Resistance Reveal Drug Targets to Circumvent Resistance

, 2023
Xu Zhang, Tapan Kumar Maity, Karen Ross, Yue Qi, Constance M. Cultraro, Meriam Bahta, Stephanie Pitts, Meghana Keswani, Shaojian Gao, Khoa Dang P. Nguyen, Julie Cowart, Fatos Kirkali, Cathy Wu, Udayan Guha   +13 more
openalex   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

pUL135 and pUL138 impact phosphorylation of EGFR.

, 2016
Buehler Jason, Zeltzer Sebastian, Reitsma Justin, Petrucelli Alex, Mahadevaiah Umashankar, Rak Mike, Patricia Zagallo, Schroeder Joyce, Terhune Scott, Goodrum Felicia   +9 more
openalex   +2 more sources

439O Tracking spatiotemporal T790M heterogeneity in patients with EGFR-mutant advanced NSCLC after acquired resistance to EGFR TKIs [PDF]

, 2016
Y.-C. Zhang, Can Pi, E.-E. Ke, Zhendong Chen, Jian Su, Zhong‐Yi Dong, Chong‐Rui Xu, Hong‐Hong Yan, Hai‐Yan Tu, Wen‐Zhao Zhong, X.-C. Zhang, Jin‐Ji Yang, Xue Yang, Qing Zhou, Yi‐Long Wu   +14 more
openalex   +1 more source