Results 51 to 60 of about 493,439 (210)

Real‐World Safety of Concomitant Colchicine and Statin Therapy

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the risk of clinically meaningful muscle‐ and liver‐related outcomes associated with concomitant colchicine–statin therapy in a real‐world setting, and to determine whether concomitant therapy increases the incidence of toxicity compared with either agent alone.
Roni Meidan, Ranel Loutati, Dan Caspi, Ori Elkayam, Ran Abuhasira, Tali Eviatar   +5 more
wiley   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source

Consensus for EGFR mutation testing in non-small cell lung cancer: results from a European workshop

, 2010
INTRODUCTION: Activating somatic mutations of the tyrosine kinase domain of epidermal growth factor receptor (EGFR) have recently been characterized in a subset of patients with advanced non-small cell lung cancer (NSCLC).
Egbert Smit, Christian Manegold, Miquel Taron, Dominique Grunenwald, Herth, Felix J F, Stahel, Rolf, Smit, Egbert, Rolf Stahel, Keith M. Kerr, Herth, F J F, Pirker, R, Manegold, C, Kerr, K M, Popper, H, Fred R. Hirsch, Smit, E, Dietel, M, Martin Filipits, Marchetti, Antonio, Michael Thomas, Pirker, Robert, Robert Pirker, Rosell, R, Rosell, Rafael, Schirmacher, Peter, Filipits, Martin, Stahel, R, Taron, M, Dietel, Manfred, Thomas, Michael, Gandara, D, Gandara, David, Felix J.F. Herth, Peter Schirmacher, Schirmacher, P, Cappuzzo, F, Popper, Helmut, Grunenwald, D, Hirsch, F R, Helmut Popper, Manfred Dietel, Kerr, Keith M, de Stricker, Karin, Taron, Miquel, Antonio Marchetti, Filipits, M, Grunenwald, Dominique, Marchetti, A, Manegold, Christian, David Gandara, Cappuzzo, Federico, Hirsch, Fred R, Federico Cappuzzo, Thomas, M, Rafael Rosell, Dietel M, Manegold C, Hirsch FR, Schirmacher P, Kerr, KM, Gandara D, Herth, FJF, Filipits M, Grunenwald D, Stahel R, Cappuzzo F, BUTTITTA, Fiamma, Kerr KM, Rosell R, Thomas M, Pirker R, Smit E, Taron M, Popper H, European EGFR Workshop Group, Herth FJ, Hirsch, FR   +76 more
core   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice [PDF]

, 2005
Background: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12–14 mo from the time of diagnosis.
Levitzki, Alexander, Alexander Levitzki (32255), Shir Alexei, Levitzki Alexander, Manfred Ogris, Ernst Wagner (60760), Wagner, Ernst, Ernst Wagner, Ogris Manfred, Alexander Levitzki, Ogris, Manfred, Manfred Ogris (60759), Alexei Shir (60758), Shir, Alexei, Wagner Ernst, Alexei Shir   +15 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

EGFR T790M: revealing the secrets of a gatekeeper

, 2017
Brian Ko, Daniel Paucar, Balazs Halmos Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA Abstract: Non-small-cell lung cancers that harbor activating mutations in the EGFR gene represent ...
Halmos B, Ko B, Paucar D
core  

Representative PDAC cases with different EGFR/CXCR4 expression profiles: EGFR-/CXCR4− (A), EGFR+/CXCR4− (B), EGFR-/CXCR4+ (C), and EGFR+/CXCR4+ (D). Magnification x 100.

, 2015
Representative PDAC cases with different EGFR/CXCR4 expression profiles: EGFR-/CXCR4− (A), EGFR+/CXCR4− (B), EGFR-/CXCR4+ (C), and EGFR+/CXCR4+ (D). Magnification x 100.
Huanwen Wu (697595), Liang Zhu (172992), Huadan Xue (487099), Wenze Wang (586963), Xiaohua Shi (697596), Li Zhang (8200), Hui Zhang (7197), Zhiyong Liang (580570)   +7 more
core   +1 more source

Innovative drug delivery system using EGFR-targeted engineered peptides in anaplastic thyroid cancer treatment [PDF]

, 2023
peer reviewedAbstract: Anaplastic thyroid carcinoma (ATC) represents the most aggressive and deadliest thyroid cancer in humans. Mostly affected signaling pathways in ATC are those of MAP kinase and PIP3/AKT/mTOR. The median survival of patients with ATC
Vandecasteele, Samuel, Bougard, Marine, Journe, Fabrice, Saussez, Sven, Burtea, Carmen, Laurent, Sophie, Peeters, Sarah, Daubry, Alison, Kahvecioglu, Zehra Cagla   +8 more
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source