Results 71 to 80 of about 493,439 (210)
, 2010 Background: Mutations of the epidermal growth factor receptor (EGFR) gene in non-small-cell lung cancer (NSCLC) patients predict the patients who will respond to EGFR tyrosine kinase inhibitor (TKI) treatment.
高劍虹;張逸良;蔡孟峰;吳振都;余忠仁;楊志新;李元麒;楊泮池;施金元 +1 more
core +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Second-Line Treatments after First-Line Gefitinib Therapy in Advanced Nonsmall Cell Lung Cancer
, 2011 Gefitinib is effective as first-line therapy for advanced nonsmall cell lung cancer (NSCLC). However, after failure of gefitinib, it is unknown whether any second-line regimens could lead to better outcomes.
WU, JENN-YU;SHIH, JIN-YUAN;YANG, CHIH-HSIN;CHEN, KUAN-YU;HO, CHAO-CHI;YU, CHONG-JEN;YANG, PAN-CHYR +1 more
core +1 more source
Advanced Science, EarlyView.VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho +6 more
wiley +1 more source
, 2019 Satoshi Igawa,1 Taihei Ono,1 Masashi Kasajima,1 Mikiko Ishihara,1 Yasuhiro Hiyoshi,1 Seiichiro Kusuhara,1 Noriko Nishinarita,1 Tomoya Fukui,1 Masaru Kubota,1 Jiichiro Sasaki,2 Mitsufuji Hisashi,3 Masanori Yokoba,4 Masato Katagiri,4 Katsuhiko ...
Sasaki J +13 more
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Desempenho dos marcadores EGFR, CK5, CK14, p63 e P-caderina para identificar o fenótipo basal do carcinoma de mama [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências MédicasOs estudos dos perfis de expressão gênica dos carcinomas de mama identificaram um subtipo de tumor com pior ...
Vieira, Daniella Serafin Couto
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Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading
Advanced Science, EarlyView.Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong +5 more
wiley +1 more source
Tyrphostin AG 1478 Accelerates Hydrogen Peroxide-Induced Apoptosis in A431 Cells [PDF]
, 2003 Oxidative stress is a potent inducer of apoptosis and activates protein tyrosine kinases and cytokine receptors, such as the epidermal growth factor receptor (EGFR).
Eguchi, Katsumi +4 more
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Advanced Science, EarlyView.This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian +8 more
wiley +1 more source
, 2011 Background. Epidermal growth factor receptor (EGFR) mutations are usually detected in lung adenocarcinoma and are associated with a response to EGFR tyrosine kinase inhibitors (TKIs).
WU, SHANG-GIN;CHANG, YIH-LEONG;WU, JENN-YU;YANG, CHIH-HSIN;YU, CHONG-JEN;TSAI, MENG-FENG;SHIH, JIN-YUAN;YANG, PAN-CHYR +1 more
core +1 more source